抑郁症患者治疗前后血浆皮质醇水平的变化  

Change of plasma cortisol level in patients with depression before and after treatment

作　　者：孙桂芝[1] 杨晓蓉[1] 韩媛媛[1] 刘祥[1] 王英成[1] 赵连生[1] 李涛[1] 马小红[1] 

机构地区：[1]四川大学华西心理卫生中心,成都610041

出　　处：《临床精神医学杂志》2013年第4期245-247,共3页Journal of Clinical Psychiatry

摘　　要：目的:探讨抑郁症患者治疗前后血浆皮质醇水平的变化。方法:对160例抑郁症患者给予抗抑郁药治疗6周,分别于治疗前及治疗后进行汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评估及血浆皮质醇水平检测。结果:本组治疗前后HAMD总分分别为(24.98±5.10)和(7.57±5.61);HAMA总分分别为(20.62±6.90)和(6.21±5.17);血浆皮质醇水平分别为(407.34±144.29)nmol/L和(354.64±137.13)nmol/L。治疗后HAMD总分、HAMA总分及血浆皮质醇水平较治疗前明显下降(P均<0.001);不同性别间血浆皮质醇水平差异无统计学意义(P>0.05);血浆皮质醇变化值与HAMD、HAMA减分率不相关(r=0.084,r=0.049;P均>0.05)。结论:抗抑郁药物治疗可显著降低抑郁症患者血浆皮质醇水平。Objective：To explore the change of plasma cortisol level in patients with depression before and after treatment.Method：One hundred and sixty depressed patients were treated with antidepressant drugs for 6 weeks.Before and after treatment,they were evaluated by Hamilton depression scale （HAMD） and Hamilton anxiety scale （HAMA）;and the plasma cortisol level was detected.Results：Before and after treatment,the total scores of HAMD were （24.98±5.10） and （7.57±5.61）;the total scores of HAMA were （20.62±6.90） and （6.21±5.17）;the plasma cortisol levels were （407.34±144.29）nmol/L and （354.64±137.13）nmol/L respectively.After treatment the total scores of HAMD and HAMA and the plasma cortisol level were significantly decreased than those at before treatment （all P0.001）.The plasma cortisol level between genders was no significant difference （P0.05）.There was no correlation between the change value of plasma cortisol level and the reducing ratio of HAMD or HAMA （r=0.084,r=0.049;all P0.05）.Conclusion：Antidepressant drugs can decrease the plasma cortisol level in patients with depression.

关 键 词：抑郁症 皮质醇 抗抑郁药物治疗 

分 类 号：R749.4[医药卫生—神经病学与精神病学]