抑郁症首次发病与复发患者的空间认知功能的研究  

Study of spatial cognitive function in the first-episode and recurrent patients with depressive disorder

作　　者：吴兴曲[1] 陈玖[1,2] 杨来启[1] 马文涛[1] 张彦[1] 李亚萍[1] 

机构地区：[1]中国人民解放军第三医院全军精神病防治中心,宝鸡721004 [2]中国人民解放军第四军医大学航空航天医学系心理学教研室

出　　处：《临床精神医学杂志》2013年第4期258-260,共3页Journal of Clinical Psychiatry

基　　金：军队中医药科研专项课题(10ZYX108);2012军区医药卫生科研计划项目(CLZ12JB23)

摘　　要：目的:探讨首次发病与复发的抑郁症患者空间认知功能的差异。方法:对30例首次发病的抑郁症患者(首发组)、32例复发的抑郁症患者(复发组)进行视觉空间旋转任务检测,并与30名健康志愿者(对照组)比较。结果:错误率:首发组[(16.9±5.1)%]、复发组[(33.7±7.1)%]显著高于对照组[(10.4±3.8)%],复发组显著高于首发组(P均<0.05)。反应时:首发组[(813.5±92.6)ms]、复发组[(972.6±94.5)ms]显著长于对照组[(737.1±86.5)ms],复发组显著长于首发组(P均<0.05)。线性回归分析:对照组及首发组正像及镜像错误率、反应时均随着旋转角度递增呈线性递增函数(P均<0.01);复发组没有随着旋转角度递增呈线性递增函数。结论:首发抑郁症患者因动机减弱、注意力下降致感知觉系统的识别与编码过程受损;复发抑郁症患者视觉空间认知功能受损。Objective：To explore the difference of spatial cognitive function between the first-episode and recurrent patients with depressive disorder.Method：The test of visual space rotation task was performed in 30 first-episode depression patients （first-episode group） and 32 recurrent depression patients （recurrent group）.The results were compared with 30 healthy controls （control group）.Results：Error rate in the first-episode group [（16.9±5.1）%]and recurrent group [（33.7±7.1）%] were significantly higher than control group [（10.4±3.8）%],and which in recurrent group was significantly higher than the first-episode group （all P0.05）.（2） Response time in the first-episode group [（813.5±92.6）ms] and recurrent group [（972.6±94.5）ms] were significantly longer than control group [（737.1±86.5）ms],and which in recurrent group was significantly longer than first-episode group （all P0.05）.Linear regression analysis showed that the error rates of mirror and normal in control group and first-episode group were gradually linear increasing with the angle of rotation （all P0.01）,but were not in recurrent group.Conclusion：The first-episode patients with depressive disorders are only displaying a motivational deficit that is associated with diminished attention allocation,which caused the recognition and encoding process damaged in the perceptions system.The recurrent patients with depressive disorders have the visual space cognitive function damage.

关 键 词：抑郁症 首发 复发 空间认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]