新生期大鼠注射谷氨酸单钠后导致骨质疏松  

Effects of mono sodium glutamate administered neonataly on growth and development of bone in rat

作　　者：刘浩宇[1] 刘锡仪[1] 

机构地区：[1]广东省湛江市广东医学院生化室,524023

出　　处：《中国骨质疏松杂志》2000年第4期10-12,共3页Chinese Journal of Osteoporosis

基　　金：广东省卫生厅基金资助

摘　　要：目的　观察新生期大鼠注射谷氨酸单钠破坏下丘脑弓状核对 SD大鼠骨骼生长、发育的影响。方法和结果　新生期 SD大鼠腹腔注射谷氨酸单钠 ,饲养至 10 0天 ,可导致下丘脑弓状核细胞数量明显减少 ,身长明显短于对照鼠 ;实验组胫骨长为 3.69± 0 .19cm(平均数±标准误 ) ,对照组为 4 .4 6±0 .18cm,二组比较 ,P<0 .0 1;骨骼生长发育障碍、骨小梁明显破坏 ,出现明显骨质疏松。结论　提示下丘脑弓状核参与骨骼生长。In rats treated neonatally with monosodium glutamate(MSG)the cells in hypothalamic arcuate nucleus(ARC)decreased in number significantly,as compared with the control rats.The length of body and tibia in experimental rats was shorter than that in control rats.The length of tibia was 3.69±0.19 cm in experimental group(N=21),and 4.46±0.18 cm in control group(N=22), P <0.01.Growth and development of bone was impeded severely,trabeculae were destroyed and osteoporosis appeared obviously.The results suggest that the ARC participated in the regulation and control of the growth and development of bone in rat.

关 键 词：谷氨酸单钠 下丘脑弓状核 骨骼生长发育 

分 类 号：R681.02[医药卫生—骨科学] R338.27[医药卫生—外科学]