黛安神与阿米替林治疗脑卒中后抑郁对照研究  

The efficacy of Deanxit and Amitriptyline in the treatment of post-stroke depression

作　　者：卢伟[1] 蒋波[1] 宋兴旺[1] 谭利明[1] 胡治平[1] 

机构地区：[1]湖南医科大学附属第二医院,湖南长沙410011

出　　处：《现代康复》2000年第11期1632-1633,共2页Modern Rehabilitation

摘　　要：目的 比较黛安神与阿米替林对脑卒中后抑郁的治疗效果。方法 60例首发脑卒中后伴有抑郁的患者随机分为 2组，采用单盲法分别给予黛安神和阿米替林进行治疗，于治疗前后用汉密顿抑郁量表 (HAMD)、神经功能缺损评分标准及抗抑郁药副反应量表 (ASBS)作检测。结果 黛安神对脑卒中后抑郁的疗效明显快于阿米替林，最终结果无明显差别，副作用黛安神明显少于阿米替林；黛安神组患者神经功能缺损的恢复优于阿米替林组。结论 黛安神治疗脑卒中后抑郁较阿米替林疗效快，副作用少，更利于神经功能缺损的恢复。Objective To compare the efficacy of Deanxit and Amitriptyline in the treatment of post stroke depression .Method Sixty consecutive depressed patients entered the trial 1 7 days after stroke. They were assigned to Deanxit and Amitriptyline group in randomized order. Treatment was given for periods of 4 weeks by single blindness .Patientswere assessed before and after treatment by HAMD,.CSSand SERS.Result Deanxit produced a statistically significant reduction of HAMD more quickly than Amitriptyline, but the last result has't difference. The side effect of Deanxit is less than Amitrptyline. Functional improvement of Deanxit's prior to Amitriptyline's .Conclusion Deanxit in the treatment of post stroke depression has faster efficacy ,less side effects and more benefits to the functional recovery .

关 键 词：黛安神 阿米替林 卒中后抑郁 神经功能缺损 

分 类 号：R743.305[医药卫生—神经病学与精神病学]