氯氮平对难治性精神分裂症的疗效与D4受体基因的关系分析  

A study on the relationship between the responses to clozapine for treatment refractory schizophrenia and the D4 receptor gene

作　　者：罗星光[1] 江开达[1] 顾牛范[1] 江三多[2] 杨晓敏[2] 诸索宇[2] 张永华[2] 薛振康[2] 

机构地区：[1]上海医科大学,上海200032 [2]上海市精神卫生中心

出　　处：《现代康复》2000年第11期1688-1689,共2页Modern Rehabilitation

基　　金：课题受高等学校博士学科点专项科研基金!(9748);上海医科大学临床学科重点项目基金!(97-016)。

摘　　要：目的 探讨可能与氯氮平对难治性精神分裂症疗效有关的 D4受体基因以及其它相关的因素。方法 PCR-RFLPs技术检 测 104例以氯氮平治疗的难治性精神分裂症患者的 D4受体基因。结果 发现氯氮平的疗效与男性呈正相关，与 D4受体基因及其它因素无明显相关。结论 氯氮平对男性难治性精神分裂症患者的疗效较好， D4受体基因在氯氮平的药理作用中不起重要作用。Objective To investigate the relationship between the responses to clozapine for treatment refractory schizophrenic patients and the D4 receptor gene and the other related factors.Method The D4 receptor gene in 104 treatment refractory in patients with schizophrenia had been detected by PCR-RFLPs technique.Result The responses to clozapine for treatment refractory schizophrenic patients are positively related to the male but not related to the D4 receptor gene and other factors.Conclusion The responses to clozapine for the male treatment-refractory schizophrenic patients are better than those for the female ones.D4 receptor gene may not play a key role in the action of clozapine on the treatment refractory schizophrenic patients.

关 键 词：氯氮平 难治性 精神分裂症 D4受体基因 性别 

分 类 号：R749.305[医药卫生—神经病学与精神病学]