眼部毛细血管瘤瘤内注射糖皮质激素安全性评价  

Research on the safety evaluation of the glucocorticoid injection for ocular capillary hemangioma

作　　者：刘洋[1] 黄冠南[1] 张虹[1] 宋国祥[1] 

机构地区：[1]天津医科大学第二医院眼科,天津300211

出　　处：《中国实用眼科杂志》2013年第8期1009-1012,共4页Chinese Journal of Practical Ophthalmology

基　　金：天津医科大学第二医院科研基金课题（Y1005）

摘　　要：目的评价糖皮质激素瘤内注射治疗眼部毛细血管瘤的安全性。方法对1996年1月至2011年8月在天津医科大学第二医院眼科接受糖皮质激素肿瘤内注射治疗的毛细血管瘤患儿140例。总结其临床资料，分析治疗后并发症的发生率；对出院患儿进行随访，以获得其目前身高、体重及血清钙数据，分为男女两组，分别计算和各年龄段的百分位数标准值的差值，进行秩和检验，以P〈0．05为差异有统计学意义；比较治疗前后血钙浓度，采用f检验，以P〈0．05为差异有统计学意义。结果在140例病人中，5例患儿毛发增多，4例有满月脸现象，糖皮质激素副反应的发生率为6．4％。所有的患儿在停药后的随访中均恢复正常。随访66例患者，占患儿总数的47．1％。经与该年龄段身高、体重标准值的对比分析，P〉0．05，与正常值无明显差异。检测18例患儿治疗前后血清钙浓度，治疗前后差异无统计学意义（P〉0．05）。结论糖皮质激素瘤内注射治疗眼部毛细血管瘤安全、有效、副反应少，对儿童及青少年的生长发育无明显影响。Objective To evaluate the safety on the treatment of ocular capillary hemangioma with intratumoral injection of glucocorticoid. Methods One hundred and forty eases of children who received treatment with intratumoral injection of glucocorticoid, and the clinical material was summa- rized. Analyzing the treatment of the incidence of complications; Follow-up to get its current height, weight data and serum-calcium concentrations, divided into two groups of male and female respec- tively, calculation and of all the ages percentile of the standard difference, Rank sun test and t-test to our judgment and normal children＇s growth and serum-calcium concentrations index of difference to P 〈0.05 for differences with a statistical significance. Results Complications： 5 cases had hair-in- creased phenomenon, 4 cases had full-moon face phenomenon, and glucocorticoid side effects oc- curred in 6.4%. All the children in the follow-up after withdrawal were back to normal. The fol- low-up were 66 cases, accounting for 47.1% of the total number of children, 26 males, 40 female. By analyzing the standard comparison of the age and the height and weight, P 〉0.05, 18 cases with the serum-calcium concentrations index, P 〉0.05, it was no obvious difference with the normal. Conclusions Glucocorticoid tumor therapy in ocular capillary hemangioma is safe, effective and less side effects, have no obvious effect to the growth and develonment of children and adolescents.

关 键 词：毛细血管瘤 糖皮质激素 瘤内注射 生长发育 

分 类 号：R739.7[医药卫生—肿瘤]