血管心外膜活性物质在胆囊癌中的表达及临床意义  

Expression of blood vessel epicardial substance in human gallbladder cancer and its clinical significance

作　　者：石程剑[1] 秦仁义[1] 王欣[1] 朱峰[1] 申铭[1] 田锐[1] 王敏[1] 李旭[1] 徐盟[1] 郭兴军[1] 谢晨成[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院胆胰外科,湖北武汉430030

出　　处：《中国普通外科杂志》2013年第8期994-997,共4页China Journal of General Surgery

基　　金：国家自然科学基金资助项目(81071775;81101621;81172064);湖北省自然科学基金重点资助项目(2011CDA030)

摘　　要：目的:探讨血管心外膜活性物质(BVES)在胆囊癌中的表达及其意义。方法:用免疫组化法检测65例胆囊癌组织和55例良性病变胆囊组织中BVES的表达情况,并分析BVES蛋白的表达与临床病理因素的关系。结果:BVES蛋白胆囊癌组织中高表达率为20.0%(13/65),低表达率为80.0%(52/65),而在胆囊良性病变组织中高表达率为74.5%(41/55),低表达率为25.5%(14/55),两者差异有统计学意义(χ2=35.811,P<0.05)。单因素分析显示BVES表达与胆囊癌的组织分化程度、临床分期、淋巴结转移密切相关,该3因素分组间的差异均有统计学意义(均P<0.05)。结论:BVES的低表达或者表达缺失可能在胆囊癌发生、发展中起重要作用。Objective：To study the expression of blood vessel epicardial substance（BVES） in human gallbladder cancer tissue and its clinical significance.Methods：The BVES expressions in gallbladder tissue specimens form 65 patients with gallbladder cancer and 55 cases with benign gallbladder diseases were determined by immunohistochemical staining,and the relations of BVES expression with clinicopathological profiles of gallbladder cancer were analyzed.Results：The high expression rate and low expression rate of BVES in gallbladder cancer tissues was 20.0%（13/65） and 80.0%（52/65）,which was 74.5%（41/55） and 25.5%（14/55） in benign gallbladder tissues respectively,and the difference between the two groups had statistical significance（χ2=35.811,P＆lt;0.05）.The univariate analysis indicated that the BVES expression was closely associated with the degree of differentiation,clinical stage and lymph node metastasis of the gallbladder cancer,as showed by the statistical differences of these three factors between the two groups（all P＆lt;0.05）.Conclusion：The low or lack of BVES expression may be closely connected to the occurrence and development of gallbladder cancer.

关 键 词：胆囊肿瘤 血管心外膜活性物质 肿瘤标记 生物学 

分 类 号：R735.8[医药卫生—肿瘤]