氩氦冷冻治疗9L/Fischer344大鼠脑胶质瘤疗效观察  

Efficacy of argon-helium cryosurgery for gliomas in 9L/Fischer344 rats

作　　者：刘剑[1] 马国亮[1] 夏爱祥[2] 张世忠[3] 黄传平[1] 林武鹏[1] 王德才[1] 

机构地区：[1]解放军421医院,广州510318 [2]解放军305医院,北京100017 [3]南方医科大学珠江医院神经外科,广州510280

出　　处：《中国微侵袭神经外科杂志》2013年第8期376-378,共3页Chinese Journal of Minimally Invasive Neurosurgery

基　　金：国家自然科学基金(编号:81172416)

摘　　要：目的研究氩氦冷冻治疗9L/Fischer344大鼠脑胶质瘤的疗效及预后。方法 Fischer344大鼠胶质瘤模型建立成功后,随机分为空白对照组、手术组、氩氦冷冻组,每组10只。游标卡尺测量并计算肿瘤体积,观察各组大鼠行为及生存期。结果空白对照组、手术组和氩氦冷冻组大鼠生存时间分别为(78.5±1.1)d、(171.0±10.8)d和(252.8±5.0)d,差异具有统计学意义(P=0.002)。氩氦冷冻组肿瘤体积呈逐渐缩小趋势。结论氩氦冷冻是治疗胶质瘤有效方法,推测可能与瘤细胞破裂,抗原暴露,而刺激机体产生抗肿瘤的抗体有关。Objective To research the efficacy of argon-helium cryotherapy for glioma and the prognosis in 9L/Fischer344 rats. Methods Fischer344 rat glioma models were successfully established and divided into blank control group,surgery group and cryotherapy group,10 rats each.The size of the tumor was measured and calculated by vernier caliper.The behavior and survival of rats was observed before and after cryotherapy.Results The survival time in blank control group,surgery group and cryotherapy group was 78.5±1.1,171.0±10.8 and 252.8±5.0 days respectively,and the difference was statistically significant（P = 0.002）.The tumor volume showed a trend to decrease in cryotherapy group.Conclusions Cryosurgery is an effective treatment for glioma, presumably due to the tumor cell rupture-caused antigen exposure stimulating the body to produce anti-tumor antibodies.

关 键 词：神经胶质瘤 冷冻疗法 氩氦 大鼠 近交F344 

分 类 号：R739.41[医药卫生—肿瘤]