中性粒细胞-淋巴细胞比值预测肝细胞癌患者TACE术后预后  

Prognostic significance of blood neutrophil-to-lymphocyte ratio in patients with hepatocellular carcinoma undergoing TACE

作　　者：郑游冰[1] 赵炜[1] 刘冰[1] 李勇[1] 胡宝山[1] 陆骊工[1] 

机构地区：[1]广东省医学科学院广东省人民医院肿瘤中心介入治疗科,广东广州510080

出　　处：《中国介入影像与治疗学》2013年第9期523-526,共4页Chinese Journal of Interventional Imaging and Therapy

摘　　要：目的探讨中性粒细胞-淋巴细胞比值(NLR)预测肝细胞癌(HCC)患者TACE后预后的价值。方法回顾性分析接受TACE治疗的HCC患者77例,计算术前、术后NLR,分析NLR与临床病理特征和预后的关系。结果以NLR=4为界,术前高NLR组(NLR≥4)和低NLR组(NLR<4)患者临床基线资料的差异均无统计学意义(P均>0.05);术前高NLR组患者中位总生存期短于低NLR组,分别为7.8个月和16.0个月(P=0.028)。多因素分析显示术前NLR≥4(P=0.01)、肿瘤≥5cm(P=0.01)是影响预后的独立危险因素。结论 NLR是预测HCC患者TACE术后预后的指标之一;术前NLR≥4者生存期较短。Objective To explore the prognostic significance of blood neutrophil-to-lymphocyte ratio （NLR） in patients with hepatocellular carcinoma （HCC） who underwent TACE. Mehtods A total of 77 patients with HCC initially treated with TACE were retrospectively analyzed. The relationship between NLR and clinicopathologic features/survival were observed. Results The clinicopathologic features between patients with a high NLR （≥4） and those with lower NLR （~4） did not differ significantly （all P〉0.05）. The median survival in patients with a high NLR and a low NLR was 7.8 and 16.0 months, respectively （P=0. 028）. Multivariate analysis showed that NLR≥4 （P=0.01） and tumor size≥5 cm （P= 0.01） were independent prognostic factors for poor survival. Conclusion The NLR can predict poor survival in patients with HCC treated with TACE. Patients with NLR≥4 before TACE have short survival period.

关 键 词：肝肿瘤 化学栓塞 治疗性 中性粒细胞淋巴细胞比值 生存期 

分 类 号：R735.7[医药卫生—肿瘤] R445[医药卫生—临床医学]