奥氮平联用丙戊酸钠治疗男性双相障碍躁狂发作的疗效对照研究  

Research on the Effect of sodium valproate combined with olanzapine in the treatment of Male manic episodes of bipolar disorder

作　　者：朱永坚[1] 徐昌武[1] 郑朝盾[1] 蒲绮霞[1] 陈庆强[1] 

机构地区：[1]广州市脑科医院,广东广州510370

出　　处：《现代诊断与治疗》2013年第7期1463-1465,共3页Modern Diagnosis and Treatment

摘　　要：目的探讨奥氮平联用丙戊酸钠治疗男性双相障碍躁狂发作的疗效与安全性。方法选择在我院住院的、符合美国精神疾病诊断和统计手册(DSM-IV)中双相障碍急性躁狂发作的男性患者88例,随机分为两组。观察组使用奥氮平联用丙戊酸钠治疗,对照组使用喹硫平联用丙戊酸钠治疗。对两组在治疗前及治疗6周后进行Bech.Rafaelsen躁狂量表(BRMS)评定评价疗效,及进行治疗后副作用量表(TESS)评定评价安全性。结果观察组治疗6周后,BRMS减分明显,显效率高于对照组;且副作用少而轻。结论奥氮平联用丙戊酸钠治疗双相障碍躁狂发作的疗效与安全性,不亚于已经达到公认的喹硫平对双相障碍的治疗作用。Objective To explore the effect and security of sodium valproate combined with olanzapine in the treatment of male manic episodes of bipolar disorder. Methods In our hospital, accordance with the Unit- ed States of America diagnostic and Statistical Manual of mental disorders （ DSM-IV ）, 88 patients with bi- polar disorder in male patients with acute manic episode, were randomly divided into two groups. The ob- servation group was used of olanzapine combined with sodium valproate, the control group using quetiapine combined with sodium valproate. In the two groups, before treatment and 6 weeks after Bech, Rafaelsen Mania Rating Scale （ BRMS ） and the therapeutic effect was evaluated after treatment, side effects scale （ TESS ） assessment of safety evaluation. Results The observation group after 6 weeks of treatment, BRMS decreased significantly, the effective rate was higher than the control group; And the side effect is little and light. Conclusion Olanzapine Combined with sodium valproate in the treatment of bipolar disorder, clinical efficacy and safety of manic episode, has reached the therapeutic effect of quetiapine recognized of bipolar disorder.

关 键 词：药物 双相障碍 治疗 

分 类 号：R749.41[医药卫生—神经病学与精神病学]