磁共振表观扩散系数对鼻咽癌放疗后复发与纤维化的鉴别诊断价值  

Diagnostic Value of MRI Apparent Diffusion Coefficient on Recurrent Nasopharyngeal Carcinoma and Radiofibrosis

作　　者：钟贻洪[1] 李金高[2] 钟俊远[1] 郭小青[1] 雷剑[1] 

机构地区：[1]江西省赣州市人民医院,341000 [2]江西省肿瘤医院,330029

出　　处：《实用癌症杂志》2013年第3期288-291,共4页The Practical Journal of Cancer

摘　　要：目的探讨ADC值对鼻咽癌放疗后复发及纤维化的鉴别诊断价值。方法回顾性分析27例初治、21例放疗后复发和18例放疗后纤维化鼻咽癌患者的ADC图,并测量病灶、对侧肌肉、鼻腔黏膜的ADC值,比较ADC值。结果初治鼻咽癌及放疗后复发鼻咽癌者ADC图均呈低信号,放疗后纤维化鼻咽癌者ADC图呈混杂信号;初治鼻咽癌者平均ADC值为(0.678±0.132)×10-3mm2/s,95%可信区间为(0.602-0.711)×10-3mm2/s;放疗后复发鼻咽癌平均ADC值为(0.693±0.181)×10-3mm2/s,其95%可信区间为(0.611-0.753)×10-3mm2/s;鼻咽癌放疗后纤维化平均ADC值为(1.139±0.172)×10-3mm2/s,其95%可信区间为(1.137-1.196)×10-3mm2/s;对侧肌肉的平均ADC值为(1.129±0.170)×10-3mm2/s;鼻腔粘膜的平均ADC值为(1.901±0.055)×10-3mm2/s;初治鼻咽癌与复发病灶两者ADC值比较无明显差异;放疗后局部复发和纤维化两者ADC值比较有显著性差异(P<0.01)。结论 ADC值对鼻咽癌放疗后复发与纤维化的鉴别具有显著意义。Objective To investigate the values of apparent diffusion coefficient（ADC） in differential diagnosis of recurrent nasopharyngeal carcinoma and radiofibrosis.Methods ADC map findings were reviewed in 27 nasopharyngeal carcinoma cases,20 recurrent nasopharyngeal carcinoma cases and 16 radiofibrosis cases.ADC values of focus,medial pterygoid and inferior turbinate mucosa were retrospectively measured.Results Recurrent nasopharyngeal carcinoma showed obviously low signal,radiofibrosis showed sophisticated signal.The mean ADC values of nasopharyngeal carcinoma was（0.678±0.132）×10-3mm2/s,95% confidence interval was（0.602-0.711）×10-3mm2/s.The mean ADC values of recurrent nasopharyngeal carcinoma was（0.693±0.181）×10-3mm2/s,95% confidence interval was（0.611-0.753）×10-3mm2/s;The mean ADC values of radiofibrosis was（1.139±0.172）×10-3mm2/s,95% confidence interval was（1.137-1.196）×10-3mm2/s.The mean ADC values of medial pterygoid was（1.129±0.170）×10-3mm2/s.The mean ADC values of Inferior turbinate mucosa was（1.901±0.055）×10-3mm2/s.There was significant difference in ADC value between recurrent nasopharyngeal carcinoma and radiofibrosis.Conclusion ADC value has signicant importance in differentiating recurrent nasopharyngeal carcinoma and radiofibrosis.

关 键 词：鼻咽癌 复发 纤维化 弥散加权成像 表观弥散系数 

分 类 号：R739.63[医药卫生—肿瘤]