TBX2和P16蛋白在宫颈鳞癌组织中的表达及临床意义  

Expressions of TBX2 and P16 protein in cervical squamous cell carcinoma and clini cal significance

作　　者：白雪[1] 李冬梅[2] 李锐[3] 黄可敬[4] 

机构地区：[1]中国人民解放军第二零二医院,辽宁沈阳110003 [2]长春大学特殊教育学院 [3]吉林省人民医院病理科 [4]吉林省长春市中心血站

出　　处：《中国妇幼保健》2013年第26期4358-4360,共3页Maternal and Child Health Care of China

基　　金：吉林省教育厅科研课题〔2012460〕

摘　　要：目的:探讨TBX2和P16蛋白在宫颈鳞癌组织中的表达及其与宫颈癌临床病理特征的关系。方法:采用免疫组织化学技术,检测60例子宫颈鳞癌、40例宫颈原位癌(CINⅢ)和20例癌旁正常宫颈上皮(NCE)中TBX2和P16蛋白的表达,分析其表达与宫颈鳞癌的临床分期、病理类型及有无淋巴结转移的关系。结果:TBX2在宫颈鳞癌、原位癌和NCE中的阳性表达率分别为86.67%、82.50%、30.00%;P16为88.33%、87.50%、0%。与NCE组比较,TBX2和P16在鳞癌组及原位癌组阳性表达显著增高有统计学意义(P<0.001);TBX2和P16的阳性表达率与临床分期、病理类型及有无淋巴结转移均有关(P<0.01);TBX2和P16在宫颈鳞癌的表达中呈正相关(r=0.66;P=0.039;P<0.05)。结论:TBX2和P16在宫颈癌组织中表达水平的上调,两者可能是宫颈癌发生、发展的促进因子,并为宫颈癌的早期诊断、治疗及预后提供依据。Objective： To investigate the expressions of TBX2 and P16 protein in cervical squamous cell carcinoma and the rela- tionship with clinical pathological characteristics of cervical cancer. Methods： Expressions of TBX2 and P16 protein in 60 case,＇ of squamous cervical carcinoma , 40 case of cervical carcinoma in situ （ CIN l~ ） and 20 case of adjacent normal cervical epithelium （NCE） were meas- ured by using immunohistochemical technique, relationships between their clinical expressions and cervical squamous cell carcinoma staging, pathological type and lymph node metastasis were analyzed. Results： The positive expression of TBX2 in cervical squamous cell carcinoma, carcinoma in situ and in NCE rates were 86. 67%, 82. 5% and 30% , P16 were 88.33% , 87. 5% and 0% resprectively. Compared with group NCE, positive expressions of TBX2 and P16 in squamous cell carcinoma and carcinoma in situ of were increased significantly （P 〈 0. 001 ）; the positive expression rates of TBX2 and P16 were relatede with clinical staging, pathological type and lymph node metastasis （P 〈 0. 01 ）. TBX2 was positively correlated with P16 expression in cervical squamous cell carcinoma （r = 0. 66 ; P = 0. 039 ; P 〈 0. 05） . Conclusion： The expressions of TBX2 and P16 in the tissues of cervical cancer, two cervical cancer, may promote the development of the factors, and to provide evidence for early diagnosis, treatment and prognosis of cervical cancer.

关 键 词：宫颈癌 免疫组织化学 TBX2 P16 

分 类 号：R737.33[医药卫生—肿瘤]