Synthesis of Novel Flavanone Derivatives and Their Anti Staphylococcus aureus Evaluation  

作　　者：XU Qing-hui LI Jl-zhen HE Jiang-hua ZHAO Xin HUO Qi-sheng 

机构地区：[1]Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130021, P. R. China [2]State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changehun 130012, P R. China

出　　处：《Chemical Research in Chinese Universities》2013年第4期695-698,共4页高等学校化学研究（英文版）

摘　　要：The authors synthesized two novel flavanones bearing iso-pentenyl side chain and evaluated their anti Staphylococcus aureus（S.aureus） activity.The target compounds 7a[2-5＇-（l＂,2＂-dimethylallyl）-2＇-methoxy-4＇,5,7-tetrahydroxyflavanone] and 7b[2-5＇-（l＂,2＂-dimethylallyl）-3＇-methoxy-4＇,5,7-tetrahydroxyflavanone] were synthesized respectively through total four steps starting from 2,4,6-trihydroxy acetophenone（3） and the corresponding iso-pentenyl substituted benzaldehyde（1）,in which the 1,2-dimethyl-2-propenyl group had been introduced previously via abnormal Claisen rearrangement.The bioactivities of the two flavanones against S.aureus strains ATCC 25923,29213,and MRSA 252 were evaluated,showing the same minimum inhibitory concentration（MIC） value of 16 μg/mL.The authors synthesized two novel flavanones bearing iso-pentenyl side chain and evaluated their anti Staphylococcus aureus（S.aureus） activity.The target compounds 7a[2-5＇-（l＂,2＂-dimethylallyl）-2＇-methoxy-4＇,5,7-tetrahydroxyflavanone] and 7b[2-5＇-（l＂,2＂-dimethylallyl）-3＇-methoxy-4＇,5,7-tetrahydroxyflavanone] were synthesized respectively through total four steps starting from 2,4,6-trihydroxy acetophenone（3） and the corresponding iso-pentenyl substituted benzaldehyde（1）,in which the 1,2-dimethyl-2-propenyl group had been introduced previously via abnormal Claisen rearrangement.The bioactivities of the two flavanones against S.aureus strains ATCC 25923,29213,and MRSA 252 were evaluated,showing the same minimum inhibitory concentration（MIC） value of 16 μg/mL.

关 键 词：FLAVANONE Abnormal Claisen rearrangement ANTIMICROBIAL iso-Pentenyl side chain 

分 类 号：TQ463.53[化学工程—制药化工] TS207.4[轻工技术与工程—食品科学]