C-MYC基因检测对宫颈高级别病变诊断价值的Meta分析  

To Evaluate the Diagnostic Value of C-MYC Gene on High Grade Squamous Intraepithelial Lesion of Cervix:A Meta-analysis

作　　者：欧亚梦兰[1] 李力[1] 高琨[1] 

机构地区：[1]广西医科大学附属肿瘤医院妇瘤科,广西区域高发肿瘤防治重点实验室,南宁530021

出　　处：《国际妇产科学杂志》2013年第4期314-317,共4页Journal of International Obstetrics and Gynecology

基　　金：广西科技厅攻关项目(桂科攻10124001A-34)

摘　　要：目的：系统评价C-MYC基因对宫颈高级别病变（≥CINⅡ）的诊断价值。方法：计算机检索PubMed、EMbase、Cochrane Library、CBM等数据库,检索期限可查数据至2012年3月31日。根据诊断性试验准确性质量评价工具（QUADAS）评价文献质量并提取数据,采用Meta-Disc 1.4版软件进行Meta分析。结果：C-MYC基因7篇文献符合纳入标准入组本系统评价,合并统计量1 180例。Meta分析的结果显示：C-MYC基因诊断宫颈高级别病变敏感度、特异度和诊断比值比分别为0.52（95%CI为0.47~0.57）、0.80（95%CI为0.77~0.83）和3.60（95%CI为1.55~8.39）。结论：C-MYC基因用于单独检测宫颈高级别病变的诊断价值中等,可作为临床辅助其他诊断方法的一种可选方法。Objective：To evaluate the diagnostic value of C-MYC gene on high grade squamous intraepithelial lesions of cervix.Methods：We search the database of PubMed,EMbase,Cochrane Library,CBMR and etc,from checkable date to March 31,2012.We evaluate documents quality based on the diagnostic test accuracy quality evaluation tools（QUADAS）and the studies meet the requirements were included,data analysis was conducted by Meta-Disc 1.4 software.Results：7 studies with a total of 1180 cases in C-MYC gene were included.The results of meta-analysis showed that the sensitivity,specificity,diagnostic odds ratio of C-MYC gene on high grade squamous ontraepithelial lesion of cervix were 0.52（95% CI 0.47-0.57）,0.80（95% CI 0.77-0.83）,3.60（95% CI 1.55-8.39）,respectively.Conclusions：Diagnosis value of C-MYC gene were medium in alone diagnosis high grade squamous ontraepithelial lesion of cervix,and it can be used as an auxiliary clinical diagnosis method with other diagnostic method.

关 键 词：基因 myc 宫颈肿瘤 META分析 诊断 

分 类 号：R737.33[医药卫生—肿瘤]