肿瘤相关巨噬细胞的过表达示腋下淋巴结阴性乳腺癌预后不良  

High - infiltration of tumor - associated macrophages predicted unfavorable clinical outcome for node - negative breast cancer

作　　者：张悦[1] 张清媛[1] 马文杰[1] 甄丽娜[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院肿瘤内科,哈尔滨150081

出　　处：《实用肿瘤学杂志》2013年第4期289-294,共6页Practical Oncology Journal

基　　金：黑龙江省教育厅海外学人科研资助项目（1154h19）

摘　　要：目的探讨肿瘤间质内肿瘤相关臣噬细胞（ Tumor - associated macrophages, TAM）表达与腋下淋巴结阴性乳腺癌患者预后的关系。方法应用免疫组织化学染色法检测172例乳腺癌标本中肿瘤相关巨噬细胞的表达，分析巨噬细胞表达与乳腺癌临床病理因素及预后的关系。结果肿瘤相关巨噬细胞高表达乳腺癌患者其预后比低表达患者差。腋下淋巴结阴性乳腺癌患者，肿瘤相关巨噬细胞高表达患者预后比低表达患者差。Cox多因素分析显示肿瘤相关巨噬细胞是乳腺癌预后不良的独立危险因素。结论对于腋下淋巴结无转移乳腺癌患者，肿瘤相关巨噬细胞高表达提示预后不良，肿瘤相关巨噬细胞可成为判断预后的免疫指标之一。Objecive To explore the significance of expression of tumor - associated macrophages （TAM） in node - negative breast cancer. Methods Immunohistochemical staining was used to analyze TAMs ex- pression levels in patients with breast cancer and compared these data with the clinicopathological features of these patients. Results Breast cancer patients with TAMs high - infiltration had significantly lower DFS and 5 - year survival rates than patients with TAMs low - infiltration. For patients with negative axillary lymph node me- tastasis, high - infiltration of TAMs indicated markedly poorer survival rate than low - infiltration arm. Multivariate analysis further confirmed that increased density of TAMs was an independent prognostic factor for patients with breast cancer. Conclusion High infiltration of TAM indicated poor survival rate for patients with node - negative breast cancer. The infiltration of TAMs is a new and impo ＂rtant risk factor for node - negative breast cancer recur-rence.

关 键 词：腋下淋巴结阴性乳腺癌 肿瘤相关巨噬细胞 生存 

分 类 号：R737.9[医药卫生—肿瘤]