不同年龄组胃癌的发病特点及临床病理分析  

The clinical characteristics and pathological features of gastric cancer in different age groups

作　　者：赵娟[1] 顾园龙[1] 徐京京[1] 娄长杰[1] 燕飞虎[1] 张艳桥[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院,哈尔滨150081

出　　处：《实用肿瘤学杂志》2013年第4期328-333,共6页Practical Oncology Journal

摘　　要：目的探讨不同年龄组胃癌患者临床发病特点及临床病理的差异。方法回顾性分析2005年1月-2007年1月在哈尔滨医科大学附属肿瘤医院治疗的1138例胃癌患者临床资料；按年龄分为：A组≤40岁；B组41-70岁；C组〉70岁，对各组的基本情况、主要症状、肿瘤发生部位、病理类型及临床分期进行统计学分析，比较各组之间的差异。结果胃癌发病例数随年龄增长而升高，51-70岁为高峰年龄段，在加岁之前，女性发病例数高于男性（P〈0．05），40岁之后男性发病例数高于女性；与B、C两组相比，A组具有肿瘤家族史者比例更高，差异具有统计学意义（P〈0．05）；与A组相比，B、C组患者喜盐食、酸菜、热食者及烟酒嗜好者比例较高，差异具有统计学意义（P〈0．05）；首发症状主要为上腹痛、腹胀，纳差等，三组无统计学差异（P〉0．05）；与B、C两组相比，A组胃窦癌所占比例更高，差异具有统计学意义（P〈0．05），随年龄增长胃底贲门癌比例增长；病理类型以低分化腺癌为主；与B、C两组相比，A组粘液腺癌和印戒细胞癌比例较高，差异具有统计学意义（P〈0．05），随年龄增长高中分化腺癌增多；TNM分期以Ⅱ期和Ⅲ期为主，与B、C组相比，A组Ⅳ期患者比例较高，差异具有统计学意义（P〈0．05）。结论不同年龄组胃癌患者具有不同的发病特点和病理特征。Objective To investigate clinical characteristics and pathological features of gastric cancer of different age groups. Methods 1 138 cases of clinical data of patients with gastric cancer from January 2005 to January 2007 at the Third Affiliated Hospital of Harbin Medical University were retrospectively analyzed. Accord- ing to ages, patients were divided into 3 groups ： A ≤ 40 years; B 〉 40 years and≤ 70 years ; C 〉 70 years. The whole group and the groups＇demographic factors, the main symptoms, tumor location, pathological type and TNM stage were statistically analyzed and compared. Results The number of gastric cancer increased along with the age and reached a high peak in 51 -70 years. Female patients predominated at the cases of 40 years or younger （ P 〈 0.05 ）. Patients in A group had a higher percentage off amily history of cancer（P 〈 0.05 ）. Lots of patients in B and C groups liked heavier salty foods,hot foods,smoking and alcohol drinking than patients in A groups（P 〈 0.05）. Initial symptoms in these three groups were similar（P 〉 0.05 ）. Most of tumors occurred at pyloric an- trum in A group （ P 〈 0.05 ）, gastric cardia and funduscancer increased along with the age, especially male pa- tients. The majority of patients were the low differentiated adenocarcinoma. High and middle differentiated adeno- carcinoma ratio increased along with the age. The A group had more mucinous adenocarcinoma and signet - ring cell carcinoma than the other groups（ P 〈 0.05）. The majority of patients belonged to stage Ⅱ and Ⅲ. The A group had more stage IV patients （P 〈 0.05 ）. Conclusion Gastric cancer patients of different age groups have different characteristics of the disease and pathological features.

关 键 词：胃癌 年龄 发病特点 病理特征 

分 类 号：R735.2[医药卫生—肿瘤]