冷藏能降低苄达赖氨酸滴眼液的刺激性  

Reduction in stimulation of bendazac lysine eyedrops by cold storage

作　　者：曾晓瑜 林荣霞[2] 张银锑 戴南平[3] 高逸龙 沈建平[3] 严汉英 

机构地区：[1]浙江省平湖市药物研究所,314200 [2]江苏省人民医院,210000 [3]南京医科大学,210000

出　　处：《眼科新进展》2000年第5期322-324,共3页Recent Advances in Ophthalmology

基　　金：浙江省科技计划项目!(编号 :98-2-109)

摘　　要：目的　分别滴用室温保存和冰箱冷藏后的苄达赖氨酸滴眼液 ,判断冷藏后的苄达赖氨酸滴眼液能否降低对眼的刺激。方法　对照眼 80例 ,滴用室温保存的本眼药液 ,试验眼 80例 ,滴用冰箱冷藏后的苄达赖氨酸滴眼液 ,男女各半 ,按配对设计方案双盲法进行。结果　滴眼后眼球刺激的出现率 :对照眼为 19.38% ,受试眼为 6 .2 5 % ;出现 B级和 C级反应者 :对照眼为 31例 ,试验眼为 10例 ;平均刺激等级 :对照眼为 1.2 1,试验眼为 1.0 7。经秩和检验 ,两者有显著差异。出现局部刺激性记分改变 :对照眼为 1.5 7± 1.5 0 ,试验眼为0 .79± 1.40 ,两者有显著性差异 ;眼球出现刺激的开始反应时间及刺激反应的持续时间两者无显著差异。结论　滴用冰箱冷藏后的滴眼液“一过性灼烧感”在刺激反应发生率和反应程度上 ,均比滴用在室温下保存的滴眼液有明显的改善 (P<0 .0 1)Objective To evaluate whether the stimulation on eyes of bendazac lysine eyedrops could be reduced by cold storage.Methods Mate design scheme and double blind clinical trial were performed. 160 healthy eyes was divided into two groups: the test group was given bendazac lysine eyedrops which was stored in refrigerator at 4℃ over night, and the control group was given it which was stored at room temperature.Results ln the control group and the test group, the occuring rate of stimulation was 19.30% and 6.25%. The cases of B、C stimulation degrees were 31 and 10; the average stimulation degrees of each group were 1.21 and 1.07, the scoring change for eye stimulation were 1.57±1.50,0.79±1.40,all respectively. The statistical difference was significant ( P <0.05 or P <0.01).Conclusion The eye stimulation of bendazac lysine eyedrops can be reduced by cold storage.

关 键 词：苄达赖氨酸 滴眼液 冷藏 刺激性 

分 类 号：R977.4[医药卫生—药品] R988.1[医药卫生—药学]