添加不同抗菌剂的纳米增强义齿基托树脂对变形链球菌黏附性能的影响  

Effect of different inorganic antibacterial agent on bacteria adhesion of nano-enhanced polymethymethacrylate denture base resin

作　　者：陈荣荣[1] 张修银[1] 杨瑞[1] 黄卓砾[1] 朱彩莲[2] 

机构地区：[1]上海交通大学医学院附属第九人民医院口腔修复科 [2]上海市口腔医学研究所,上海市口腔医学重点实验室,上海200011

出　　处：《口腔材料器械杂志》2013年第3期126-130,共5页Chinese Journal of Dental Materials and Devices

基　　金：上海市科学技术委员会重点基金项目(09JCl408900)

摘　　要：目的研究添加不同抗菌剂的纳米增强聚甲基丙烯酸甲酯(PMMA)基托树脂对变形链球菌黏附性能的影响。方法将二氧化钛(TiO2)、载银二氧化钛(Ag/TiO2)、载银磷酸锆(Ag/ZrP)和四针状氧化锌晶须(T-ZnOw)均按照质量比3%分别与纳米ZrO2颗粒-硼酸铝晶须(alumina borate whiskers,ABW)/PMMA混合,合成复合材料,未添加抗菌剂的作为对照组,共5组。制作试验标准试件,进行表面粗糙度及变形链球菌黏附性能测试。采用SPSS13.0统计分析软件对数据进行分析,组间比较采用SNK检验。结果当添加抗菌成分量均为3%时,添加载银二氧化钛组的表面粗糙度值最高(P<0.05),载银二氧化钛组和载银磷酸锆组的细菌黏附量显著高于对照组(P<0.05),而二氧化钛组和四针状氧化锌晶须组的细菌黏附量低于对照组(P<0.05)。结论载银二氧化钛及载银磷酸锆可提高纳米增强PMMA义齿基托树脂表面的变形链球菌黏附。Objective To study the influence of four different antibacterial agents on the adhesion of streptococcus mutans on the surface of nano-enhanced polymethylmethacrylate（PMMA＇S） denture base resin. Methods Four different antibacterial agents （TiO2, Ag/TiO2, Ag/ZrP, T-ZnOw） were added into the ZrO2- ABW/PMMA powder in proportion of 3%wt respectively. The ZrO2-ABW/PMMA powder without adding antibacterial agent was used as control. Then the composites were synthesized and standard specimens were manufactured. The surface roughness and bacterial adhesion of all the specimens were examined. The data were statistically analyzed with SPSS 13.0 software and the SNK analysis was selected to do the post-hoc analysis. Results The surface roughness of the 3%wt Ag/TiO2 group was the highest （P〈0.05）. The bacterial adhesion value of 3%wt Ag/TiO2 and 3%wt Ag/ZrP groups were higher than that of control group （P〈0.05）, while the bacterial adhesion value of 3%wt TiO2 and 3%wt T-ZnOw groups were lower than that of control group （P〈0.05）. Conclusions： Ag/TiO2 and Ag/ZrP increased the adhesion of streptococcus mutans on the surface of nano-enhancedPMMA denture base resin.

关 键 词：抗菌剂 纳米增强PMMA 表面粗糙度 变形链球菌 黏附 

分 类 号：R783.6[医药卫生—口腔医学]