南瓜蛋白抗人慢性髓系白血病细胞系K562的作用研究  

Effect of Cucurmosin on Chronic Myeloid Leukemia K562 Cell Line

作　　者：刘庭波[1] 刘慧丽[2] 谢捷明[3] 胡建达[1] 

机构地区：[1]福建省血液病研究所,福建省血液病学重点实验室,福建医科大学附属协和医院 [2]漳州卫生职业学院,福建福州350001 [3]福建医科大学药学院,福建漳州363000

出　　处：《中国实验血液学杂志》2013年第4期891-894,共4页Journal of Experimental Hematology

基　　金：福建省血液病学重点实验室(编号2009j1004);福建省高校新世纪优秀人才计划(编号NCETFJ-0705)

摘　　要：本研究观察南瓜蛋白(Cucurmosin,CUS)在人慢性髓系白血病(CML)K562细胞-NOD/SCID小鼠的皮下移植瘤和白血病模型体内抗肿瘤活性。采用建立K562-NOD/SCID小鼠皮下移植瘤和白血病模型,分别使用二种模型评价CUS在小鼠体内的抗K562活性。结果表明,给药剂量为0.5 mg/kg和1 mg/kg的CUS对人CML皮下移植瘤的抑瘤率分别为53.45%和59.43%;而剂量为0.25 mg/kg和0.5 mg/kg的CUS给药组小鼠的生存时间分别为39.8±5.5 d和43.4±6.6 d,抑瘤率分别为24.9%和36%。结论:CUS对小鼠体内人CML细胞系K562具有显著的抑制作用。This study was aimed to investigate the antitumor effect of pumpkin protein（cucurmosin,CUS） on subcutaneous transplant tumor in chronic myeloid leukemia K562 cell-NOD/SCID mice and leukemia model.The subcutaneous transplant tumor in K562-NOD/SCID mice and leukemia model were established;using two models,the antitumor activity of CUS in mice was evaluated.The results indicated that the inhibitory rate of 0.5 mg/kg and 1 mg/kg CUS on subcutaneous transplant tumor were 53.45% and 59.43% respectively;survival time of mice received 0.25 mg/kg and 0.5 mg/kg CUS was 39.8±5.5 d and 43.4±6.6 d,antitumor rate was 24.9% and 36% respectively.It is concluded that CUS has significant inhibitory effect on mice with CML cell line K562.

关 键 词：南瓜蛋白 K562细胞 白血病模型 移植瘤模型 

分 类 号：R733.72[医药卫生—肿瘤] R979.1[医药卫生—临床医学]