SPRED1与急性髓系白血病的发病  

Relationship between Spred1and Acute Myeloid Leukemia——Review

作　　者：张艳[1] 李艳[1] 张蕊[1] 

机构地区：[1]中国医科大学附属第一医院血液科,辽宁沈阳110001

出　　处：《中国实验血液学杂志》2013年第4期1083-1087,共5页Journal of Experimental Hematology

基　　金：沈阳市科学技术项目(编号F12-277-1-21)

摘　　要：SPRED1是一种抑癌基因,其编码的SPRED1蛋白属于Sprouty相关的蛋白家族,主要分布在脑组织,可通过酪氨酸磷酸化等方式调节活性,从而对造血进行调控。SPRED1可抑制Ras-MAPK和RhoA细胞信号传导通路从而抑制肿瘤的发生。SPRED1基因失活可通过上述途径使急性髓系白血病细胞增殖、存活期延长及诱发血管新生,从而促进AML的发生。我们应用Array技术,RT-PCR技术及免疫组化等方法初步证实SPRED1在AML患者中表达减低。本文就SPRED1与急性髓系白血病的发病关系作一综述,旨在探讨白血病的发病机制,为临床诊疗提供新的靶向。SPRED1 protein coded by SPRED1 gene,a kind of tumors suppressor,belongs to Sprouty related protein family and mainly distributes in human brain.The activity of SPRED1 is mainly regulated by the tyrosine phosphorylation,which is stimulated by the hemopoietic factors.As an inhibitor of Ras-MAPK and RhoA cell signaling pathways,SPRED1 plays an important role in tumorigenesis and metastasis of solid tumor.Recently,the inactivation of SPRED1 is reported to result in proliferation,survival time extension and induction angiogenesis of AML cells.There is a clue that SPRED1 is hightly related to leukemiagenesis.Recently our study proved that the expression level of SPRED1 decreased in patients with acute myeloid leukemia（AML）.This review summarizes the recent progress of study on the relationship between SPRED1and AML,so as to explore the pathogenesis of leukemia and provide a new approach for clinical diagnosis.

关 键 词：SPRED1 急性髓系白血病 Ras-MAPK细胞信号传导通路 RhoA细胞信号传导通路 

分 类 号：R733.71[医药卫生—肿瘤]