铝碳酸镁片联合埃索美拉唑、黛力新治疗胃食管反流病60例  

Efficacy of combined aluminum magnesium carbonate,esomeprazole and Deanxit in treatment of gastroesophageal reflux disease in young or middle-aged patients with anxiety:An analysis of 60 cases

作　　者：姜齐宏[1] 陈艳[1] 王爱祥[1] 骆中华[1] 

机构地区：[1]华中科技大学同济医学院附属普爱医院消化内科,湖北省武汉市430034

出　　处：《世界华人消化杂志》2013年第23期2331-2334,共4页World Chinese Journal of Digestology

摘　　要：目的:研究分析铝碳酸镁片联合埃索美拉唑、黛力新治疗中青年胃食管反流病伴焦虑情绪的临床疗效.方法:将180例中青年患者随机分为3组.A组60例,采用埃索美拉唑+黛力新+铝碳酸镁治疗;B组60例,采用埃索美拉唑+黛力新治疗;C组60例,采用铝碳酸镁+黛力新治疗.观察3组患者的临床症状缓解情况、食管黏膜和胃黏膜的修复程度及其不良反应.结果:经治疗后,A组有效58例,总有效率为96.67%,复发1例;B组有效49例,总有效率为81.67%,复发8例;C组有效37例,总有效率为61.67%,复发23例,经过比较分析,A组的有效率、复发率及食管黏膜和胃黏膜的修复程度均好于B、C组(P<0.05),且不良反应较少.结论:铝碳酸镁片联合埃索美拉唑、黛力新治疗中青年胃食管反流病伴焦虑情绪,效果明显,可明显缓解症状,修复食管黏膜和胃黏膜.AIM： To evaluate the efficacy of combined alu- minum magnesium carbonate, esomeprazole and Deanxit in the treatment of gastroesopha- geal reflux disease in young or middle-aged pa- tients with clinical anxiety. METHODS： One hundred and eighty young or middle-aged patients were randomly and equal- ly divided into three groups： A, B and C. Group A was treated with aluminum magnesium carbonate, esomeprazole and Deanxit, group B was treated with esomeprazole and Deanxit, and group C was treated with aluminum magnesium carbonate and Deanxi. Clinical remission, extent of repair of the esophageal and gastric mucosa and adverse reactions were compared between the three groups. RESULTS： After treatment, the number of re- sponders was 58 （96.67%） in group A, 49 （81.67%） in group B, 37 （61.67%） in group C, and the number of patients developing recurrence in the three groups was 1, 8 and 23, respectively. The total response rate, recurrence rate, the extent of repair of the esophageal and gastric mucosa, and the incidence of adverse reactions were better in group A than in groups B and C （all P 〈 0.05）. CONCLUSION： Combined aluminum magne- sium carbonate, esomeprazole and Deanxit are effective in the treatment of gastroesophageal reflux disease with anxiety in terms of symptom relief and repair of the esophageal and gastric mucosa.

关 键 词：胃食管反流病 三联疗法 疗效分析 

分 类 号：R571[医药卫生—消化系统]