胃部肿瘤患者血清胸苷激酶检测的临床意义  

Gastric Tumor Patients Serum Thymidine Kinase(TK1) on Clinical Significance of Monitoring

作　　者：王朝敏[1] 张西志[1] 张先稳[1] 曹文淼[1] 

机构地区：[1]江苏省苏北人民医院,江苏扬州225001

出　　处：《哈尔滨医药》2013年第4期261-262,共2页Harbin Medical Journal

摘　　要：目的探讨血清细胞质胸苷激酶(TK1)检测在胃癌诊治中的临床价值。方法利用增强化学发光法(ECLA)检测204例胃癌患者血清TK1的含量,同时检测70例胃良性疾病和76名健康人血清中的TK1含量。结果胃癌患者TK1水平,2.36(1.28～3.75)pm/L。显著高于胃良性疾病组1.22(0.75～1.43)pm/L和正常对照组1.15(0.72～1.39)pm/L,P<0.01;而胃良性疾病组和正常对照组之间差异无统计学意义(P>0.05)。56例胃癌患者手术后血清TK1水平明显下降。胃癌患者血清TK1阳性率57.9%,远远高于其他消化道肿瘤标志物,癌胚抗原(CEA)14.8%、糖抗原(CA)199(13.8%)、CA50(17.8%)。结论血清TK1检测在胃癌诊断、判断预后、监测疗效等方面具有一定的临床应用价值。Objective Study of serum thymidine kinase 1 （ TK1 ） for detection of clinical value in the diagnosis and treatment of gastric cancer. Methods Enhanced chemiluminescence using（ECLA） content were detected in 204 cases of gastric cancer patients with TK1, and TK1 were detected in 70 cases of benign gastric diseases and 76 healthy human serum. Results The levels of TK1 in patients with gastric cancer,2.36 （ 1.28 - 3.75 ） PM/L. Significantly higher than benign gastric diseases group and 1.22 （ 0.75-1.43 ） PM/L and normal control group 1.15 （0.72 -1.39）PM/L,P 〈 0.01 ;while the difference between gastric benign disease group and normal control group had no statistical significance（ P 〉 0.05 ）. In 56 cases of gastric cancer patients after operation. Serum TK1 level de- creased significantly. The positive rate of serum TK1 in patients with gastric cancer 57.9% ,far higher than other digestive tract tumor markers, carcinoembryonic antigen （ CEA）, carbohydrate antigen 14.8% （CA） 199 （ 13.8% ）, CA50 （ 17.8% ）. Conclusion Detection of serum TK1 in gastric cancer diagnosis ,prognosis ,monitoring curative effect and has certain clinical value.

关 键 词：血清胸苷激酶 临床意义 胃部肿瘤 

分 类 号：R735.2[医药卫生—肿瘤]