益气解毒方治疗复发性单纯疱疹性角膜炎的临床观察  

Clinical observation on treatment of recurrent herpes simplex keratitis with nourishing qi and resolving toxin formulae

作　　者：俞莹[1] 缪晚虹[1] 赵峰[1] 潘雅婕[1] 石晶琳[1] 

机构地区：[1]上海中医药大学附属曙光医院眼科,上海201203

出　　处：《中国中医眼科杂志》2013年第4期245-249,共5页China Journal of Chinese Ophthalmology

基　　金：上海市卫生局科技处资助项目(2009174)

摘　　要：目的观察中药益气解毒方口服联合局部滴眼液治疗复发性单纯疱疹性角膜炎的临床疗效。方法采用随机、对照、双盲的研究方法。选择2010年1月至2012年6月在上海中医药大学附属曙光医院眼科确诊为"复发性单纯疱疹性角膜炎"的患者63例(63只眼)。对照组予免煎中药安慰剂每日1剂口服,联合更昔洛韦滴眼液每日4次;治疗组予益气解毒免煎中药颗粒剂每日1剂口服,联合更昔洛韦滴眼液每日4次。所有患者在判定为痊愈后,改为中药隔日服1剂,治疗周期为2个月。于治疗前、治疗后3 d、1周、2周、4周、8周进行症状体征评分、角膜厚度检测,评价治疗有效率和治愈率,监测不良反应,随访停药后1年的复发率。结果在治疗2周,4周,8周时2组的症状评分有统计学意义的差异(P<0.05),2周时2组体征评分有统计学意义的差异(P<0.05),2周、4周时2组总评分有统计学意义差异(P<0.05)。治疗组在1周、2周、4周、8周的有效率和治愈率皆高于对照组,但组间比较无明显差异(P>0.05)。2组间在各时间点的角膜厚度及其变化无统计学意义的差异(P>0.05)。共26例痊愈患者完成1年随访,2组复发率无明显差异(P>0.05)。结论口服益气解毒方联合局部滴眼液治疗可在一定程度上缓解患者的症状,改善体征,安全性好。但不影响疾病的病程和角膜厚度的变化。OBJECTIVE To evaluate the clinical effect of Chinese medicine of nourishing qi and resolving toxin formulae on the recurrent herpes simplex keratitis. METHODS A randomized, controlled, double-blind and prospective study was carried out from Jan. 2010 to June 2012 at Ophthalmology Department in affiliated Shuguang Hosptial of Shanghai University of TCM. Sixty-three patients （63 eyes） diagnosed as recurrent herpes simplex keratitis were enrolled and randomly divided into two groups. The control group was given a Free-fried Granula placebo daily with ganciclovir eye drops 4 times a day; meanwhile, the test group was given nourishing qi and resolving toxin granula daily dose with ganciclovir eye drops. The granula was taken every other day after the patient had been diagnosed as being healed. And the treatment was continued during two months. All symptoms and signs, corneal thickness and side effects were evaluated before and 3days, 1st week, 2nd weeks, 4th weeks and 8th weeks after the therapy. RE- SULTS There were statistical differences between the symptom scores of the two groups at 2nd week, 4th week, 8th week （P〈0.05）, and the physical signs at 2nd week respectively. Statistical differences of total scores existed between the two groups at 2nd week, 4th week（P〈0.05 ）. The effective rate and recovery rate of the test group were both high- er than those of the control group, but by the chi-square test, there was no significant difference between the two groups （P〉0.05）. No difference of corneal thickness existed between the two groups （P〉0.05）. And no side effects and adverse drug reactions were observed in the two groups. Twenty-six patients completed the one-year follow-up, and there was no significant difference in the relapse rate between the two groups （P〉 0.05）. CONCLUSIONS To some extent, adopting nourishing qi and resolving toxin formulae with eye drops, which was confirmed safety, could alleviate the patient＇s symptoms, improve signs.

关 键 词：益气解毒方 复发性 单纯疱疹性角膜炎 随机 双盲 

分 类 号：R772.21[医药卫生—眼科]