肝细胞癌患者免疫功能变化与Th1/Th2型细胞相关性的研究进展  

The Research Progress in Relationship between Immune Function and Th1 /Th2 Cell in Patients with Hepatocellular Carcinoma

作　　者：王志利[1] 徐丹凤 李闯[1] 张跃伟[1] 

机构地区：[1]大连大学附属中山医院介入科,辽宁大连116001

出　　处：《医学综述》2013年第17期3136-3139,共4页Medical Recapitulate

摘　　要：机体免疫系统是抵抗外来病原体和各种伤害的重要防御系统,Th1/Th2在机体内处于动态平衡状态,此平衡是维持机体正常免疫状态的重要因素,其失衡与许多疾病的发生、发展密切相关。肝细胞癌变过程中,有多种与癌变相关的细胞因子,而近年来关于Th1/Th2型细胞因子与肝细胞癌(HCC)的关系已成为国内外学者研究的热点。探讨逆转Th1/Th2漂移及增强Th1细胞免疫,将为HCC的免疫治疗提供新的方法。The immune system is an important defense system, which is against foreign pathogens and a variety of injuries. Th1/T2 is a dynamic equilibrium in the body ,the balance of which is important to main- tain the body＇s normal immune status, and its imbalance is closely related with the development of many diseases. There are a variety of related cytokines in the process of hepatoeareinogenesis, and in recent years, studies on Th1/Th2 type cytokines and liver cancer have become a hot spot at home and abroad. Methods to reverse the Th1/Th2 shift and enhance Thl cell-mediated immunity will provide a new method for liver cancer immunotherapy.

关 键 词：TH1 TH2型细胞因子 动态平衡 TH1 Th2漂移 肝细胞癌 

分 类 号：R735[医药卫生—肿瘤]