降纤酶治疗急性脑梗死的双盲对照研究  

The Observation of the Effect of Treating Acute Cerebral Infarction with Defibrase by Random Double blind Method

作　　者：阎少琴[1] 王丽芳[2] 吴国民 

机构地区：[1]宁夏医学院附属医院神经内科,宁夏750004 [2]宁夏煤炭职工医院内科,宁夏753000 [3]宁夏石嘴山市第一人民医院内科,石嘴山753000

出　　处：《蛇志》1999年第4期18-20,共3页Journal of Snake

摘　　要：目的　观察降纤酶治疗急性脑梗死的效果。　方法　降纤酶与安慰剂治疗进行了随机双盲对照研究。　结果　治疗组第 1 4天神经功能缺损程度的评分低于对照组 ,P <0 .0 5 ,有显著性差异。两组出院时与 1 2周患者日常生活能力 ,即 Barthel指数计分比较 :对照组出院时与 1 2周相比 ,P <0 .0 5 ,有显著性差异 ;治疗组出院时与 1 2周相比 ,P <0 .0 1 ,有显著性差异 ;对照组与治疗组二者相比 ,P <0 .0 5 ,亦有显著性差异 ,表明治疗组患者日常生活能力的改善优于对照组。纤维蛋白原含量动态观察表明 :用药前和第 2天相比变化不大 ,P >0 .0 5 ;第 4天纤维蛋白原开始下降 ,P <0 .0 5 ;第 6天维持在第 4天水平 ,第 4天和第 6天相比 ,P >0 .0 5。通过对用药前后谷丙转氨酶 ( GPT)和尿素氮 ( BUN)的动态观察表明 ,降纤酶对 GPT有降低趋势 ,对 BUN无任何影响 ,本组全部病例均未见全身出血倾向或致颅内出血之并发症发生。治疗组死亡 1例 ,死亡原因系心房纤颤 ,急性肺水肿引起的呼吸循环衰竭 ,死亡前患者神经系统症状体征无变化 ,与应用降纤酶无关。　结论　降纤酶有明显降低纤维蛋白原 ,改善微循环的作用 ,对肝肾无害 ,也未见其它并发症。由于它纯度高及特异性的与血栓表面的纤维蛋白原结合 ,因此 ,避免了尿激酶。Ojective We observed the effect of treating acute cerebral infarction with Defibrase Method The treating with Defibrase or placebo has been observed with random double blind method Results Treating group's Neural function deficit were examined less than control group's; P<0 05 there is a little difference;comparing two group's Bathel index at being discharegd from hospital and at twelfth week:comparing control group's Bathel index at being discharged from hospital and at twelfth week,P<0 05,there is a little difference;comparing treating group's Bathel index at being discharged from hospital and at twelfth week P<0 01,there is a apparent difference;comparing treating group's and control group's index,there is a apparent difference too(P<0 05),it is said,treating group's imptovenment with normal live ability,there is a apparent progress comparing with control group The dynamic observation of fibrinogen show that:comparing before treating's and second day's there is no difference,P>0 05,fibrinogenopenia is start at forth day's,sixth day's is same as forth's P>0 05 The dynamic observation of GPT and BUN show that:Ddfibrase cause GPT debase, but has no effect on BUN All patients have not general hemorrhage tendency or Cerebral hemarrhage One patient of treating gruop died The cause of death is atrial fibrillation,acute pulmonary caused respiration and circulatory failure That is not Defibrase caused Conclusion Defibrase can debase fibrinogen and improve microcirculation has no Adverse reaction to hepar and kidney has no other complication Owing to its high purity and specific combination to fibrinogen on thrombus surface,so avoid Urokinase,Streptokinase,botroxobin caused some untoward effect such as infract hemorrhage,fever and general hemorrhagic tendency Defibrase is domestic,Price is considerable,effect is significent,course of treatment is short,treating is convenient,so it is best way to treat patients with acute cerebral in fraction,it is high safty We want better effect,Debasei

关 键 词：降纤酶 急性脑梗死 双盲对照 

分 类 号：R743.330.5[医药卫生—神经病学与精神病学] R977.3[医药卫生—临床医学]