4种血清肿瘤标志物在原发性胃淋巴瘤的临床应用研究  

Clinical application of 4 serum tumor markers in primary gastric lymphoma

作　　者：黄红[1] 毛琴[1] 全胜麟[1] 杨天睿[1] 

机构地区：[1]云南省第一人民医院内干科,昆明650032

出　　处：《重庆医学》2013年第26期3117-3119,共3页Chongqing medicine

摘　　要：目的探讨定量检测血清肿瘤标志物糖类抗原125(CA125)、乳酸脱氢酶(LDH)、β2-微球蛋白(β2-MG)及血清铁蛋白(SF)水平在原发性胃淋巴瘤(PGL)中的临床意义。方法回顾分析41例PGL患者血清CA125、LDH、β2-MG、SF水平,比较他们与胃淋巴瘤病理分型、临床分期、分组、国际预后指标(IPI积分)、幽门螺杆菌(Hp)感染的关系。结果 CA125、LDH、β2-MG、SF水平在PGL患者临床分期中ⅢE+ⅣE期分别较ⅠE+ⅡE期升高,差异有统计学意义(P<0.05);IPI积分中中高危+高危组较低危+低中危组明显升高,差异有统计学意义(P<0.01)。而在病理分型、分组、Hp感染中无明显差异性。结论肿瘤标志物CA125、LDH、β2-MG、SF检测对PGL临床分期及预后判断具有重要的临床价值。Objective To investigate the clinical significance of quantitatively detecting serum cancer antigen125（CA125） ,lactate dehydrogenase（LDH） ,β2-microglobulin（β2-MG） and serum ferritin（SF） in primary gastric lymphoma（PGL）. Methods The clini- cal data in 41 cases of PGL confirmed by Pathological examination were retrospectively analyzed on the serum CA125, LDH,β2-MG and SF levels, and their relationship with the pathological type, clinical phase, grouping, international prognostic index（IPI） andHe- licobacter pylori infection were compared. Results The serum levels of CA125 ,LDH,β2-MG and SF in the Ⅲ＋ Ⅳ stage were high- er than those in the Ⅰ＋ Ⅱ stage in PGL patients（P〈0.05） ; the IPI scores in the middle-higher risk ＋ high risk group were obvi- ously higher than those in the lower risk ＋ low-middle risk group （P〈0.01）. There were no significant differences in the patho- logical type,grouping and Helicobaeter pylori infection. Conclusion Detecting the levels of CA125, LDH,β2-MG and SF has the im- portant clinical value to the clinical phase and the prognostic judgment in PGL.

关 键 词：淋巴瘤 糖类抗原125 乳酸脱氢酶 Β2-微球蛋白 血清铁蛋白 

分 类 号：R735.2[医药卫生—肿瘤]