中青年颈动脉硬化患者血浆髓过氧化物酶、颈动脉斑块类型与缺血性脑卒中关系的研究  

Relationship between Carotid Atherosclerosis,Myeloperoxidase,and Cerebral Ischemic Stroke in Young and Middle-aged Patients

作　　者：胡玉英[1] 刘泰[1] 胡跃强[1] 陈文福[1] 陈薇[1] 陈兴华[1] 

机构地区：[1]广西中医药大学第一附属医院

出　　处：《中西医结合心脑血管病杂志》2013年第8期911-912,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：广西壮族自治区卫生厅重点科研基金项目(No.重2010091)

摘　　要：目的观察中青年颈动脉粥样硬化(CAS)患者血浆髓过氧化物酶(MPO)的水平差异,探讨颈动脉斑块类型与缺血性脑卒中的相关性。方法采用ELISA方法测定120例中青年CAS患者血浆MPO水平,同时用颈动脉彩色多普勒超声检测颈动脉斑块类型,并行头部CT或MRI检查,根据临床及检查结果分为缺血性脑卒中组与非脑卒中组,比较两组患者血浆MPO水平,不同斑块类型扁平斑、软斑、硬斑及复合斑块的变化。结果中青年CAS患者缺血性脑卒中组与非脑卒中组血浆MPO水平均较正常对照组显著增高(P<0.05或P<0.01),缺血性脑卒中组MPO水平、颈动脉软斑及复合斑块检出例数及检出率均显著高于非脑卒中组(P<0.05或P<0.01)。结论中青年CAS患者缺血性脑卒中的发生与血浆MPO水平、颈动脉斑块类型密切相关。Objective To observe the relationship between carotid atherosclerosis （CAS）, myeloperoxidase （MPO）, and cerebral ischemic stroke in young and middle - aged patients. Methods The plasma MPO levels were determined with ELISA in 120 young and middle- aged patients with CAS. The patterns of carotid artery plaque were detected by carotid artery Doppler ultrasound,CT or MRI. According to clinical observation and the results, the patients were divided into cerebral ischemic stroke group and non - cerebral stroke group. The plasma MPO level and different plaque patterns were compared. Results The plasma MPO level in cerebral ische- mic stroke group and non- cerebral stroke group were significantly increased compared with normal group （P〈0.05 or P〈0.01）. The positive rate of MPO and the soft and mixed carotid plaque in cerebral isehemic stroke group were significantly increased com- pared with non - cerebral stroke group （P〈0.05 or P〈0.01）. Conclusion There was close relationship between the plasma MPO level and the patterns of the carotid plaque in young and middle- aged patients with cerebral ischemic stroke.

关 键 词：颈动脉粥样硬化 缺血性脑卒中 髓过氧化物酶 中青年 

分 类 号：R743.3[医药卫生—神经病学与精神病学]