胶原基骨在慢性牙周炎骨修复中的临床疗效观察  

Clinical efficacy of collagen-matrix bone in chronic periodontal bone grafts surgery

作　　者：王宏岩[1] 唐晓琳[1] 司伟 林莉[1] 寇育荣[1] 潘亚萍[1] 

机构地区：[1]中国医科大学附属口腔医院牙周科,沈阳110002

出　　处：《口腔医学》2013年第8期516-519,共4页Stomatology

基　　金：辽宁省科学技术计划项目(2009412001-8)

摘　　要：目的观察、评价胶原基骨材料修复牙周骨组织缺损的临床有效性和安全性。方法采用随机、双盲的方式将牙周手术患者分为2组,A组使用胶原基骨材料,B组使用瑞福纳米人工骨进行牙周植骨术,观察患者术前及术后3、6个月时牙周探诊深度、临床附着丧失、龈沟出血指数和松动度的改变及骨组织愈合情况。结果使用胶原基骨和纳米人工骨进行牙周手术后,均可明显改善患牙的牙周探诊深度、附着丧失、龈沟出血指数和松动度,与术前差异具有统计学意义(P<0.01);2种骨组织替代材料对术后临床指标的改变无统计学差异(P>0.05)。结论应用胶原基骨材料可以改善牙周临床指标,其在牙周骨组织修复中具有有效性和安全性。Objective To observe and evaluate the clinical efficacy and safety of collagen-matrix bone materials in repairing of chron- ic periodontal bone defect. Methods Patients with periodontitis were divided into 2 groups in a randomized, double-blind manner. A group received bone grafts with collagen-matrix bone materials. B group received Ruifu nano artificial bone. The probing depth （PD） , clinical attachment loss （CAL） , sulcus bleeding index （SBI） ,tooth mobility（TM） , and alveolar bone healing status were evaluated be- fore surgery and 3,6 months after surgery. Results Both collagen-matrix bone and nano artificial bone significantly decreased PD, CAL,SBI, or TM of surgery teeth （ P 〈 0.01 ）. There was no statistical difference between A and B groups （ P 〉 0.05 ）. Conclusions The application of collagen-matrix bone can improve periodontal indexes. The collagen-matrix bone materials may repair periodontal bone defect effectively and safely in periodontal bone grafts surgery.

关 键 词：慢性牙周炎 胶原基骨 纳米羟基磷灰石 牙周植骨术 

分 类 号：R781.4[医药卫生—口腔医学]