眼睑皮脂腺癌20例临床病理分析  

Sebaceous carcinoma of the eyelids:a clinicopathological study of 20 cases

作　　者：詹娜[1] 汤永飞[1] 

机构地区：[1]武汉大学人民医院病理科,武汉430060

出　　处：《诊断病理学杂志》2013年第8期474-477,482,共5页Chinese Journal of Diagnostic Pathology

摘　　要：目的分析眼睑皮脂腺癌的临床病理特点、免疫组化特征及鉴别诊断。方法结合文献对20例眼睑皮脂腺癌的临床表现、组织形态学、免疫组化及治疗与预后进行探讨。结果肿瘤由嗜碱性的皮脂腺生发细胞和分化的皮脂腺细胞组成,并形成不规则的小叶状结构。免疫组化:PCK、CK8/18、EMA和AR(+)。结论眼睑皮脂腺癌临床少见,需与鳞状细胞癌、基底细胞癌相鉴别。组织化学及免疫组化染色有助于皮脂腺癌的病理诊断鉴别诊断。Objective To study the clinicopathologic features, immunohistochemical staning and differential diagnosis in sebaceous carcinoma （SC） of the eyelids. Methods The clinical manifestations, histopathological features, immunohistochemisty, treatment and prognosis were analyzed in 20 cases of SC with review of the literature. Results Tumor cells infiltrated in a lobular pattern. They consisted of atypical sebaceous germinative cells （seboblasts） with a high nucleus/cytoplasm ratio at the periphery, and mature sebocytes exhibiting bubbly clear cytoplasm as lipid accumulates in the center. The expression of epithelial membrane antigen （EMA）, CK8/18, PCK, and AR was detected in all carcinomas. Conclusion The histopathologic diagnosis of sebaceous carcinoma can be challenging and it is often misdiagnosed as other neoplasms, particularly squamous cell carcinoma or basal cell carcinoma. However, based on the typical histopathologic features of this entity and the histochemical and immunohistochemical reactions, the diagnosis can generally be established.

关 键 词：皮脂腺癌 眼睑 鉴别诊断 组织化学 免疫组化 

分 类 号：R739.71[医药卫生—肿瘤]