PPARγ ERα和ERβ在子宫内膜癌的表达及其相关性分析  

Correlations among the expressions of PPARγ, ERα, and ERβ in endometrial carcinoma

作　　者：侯新新[1] 赵萌[1] 王红霞[2] 张贵宇[1] 

机构地区：[1]山东大学齐鲁医院妇产科,济南市250012 [2]山东大学附属济南市中心医院妇产科

出　　处：《中国肿瘤临床》2013年第17期1029-1033,共5页Chinese Journal of Clinical Oncology

基　　金：山东省自然科学基金项目(编号:ZR2010HM102)资助~~

摘　　要：目的:探讨PPARγ、ERα和ERβ在子宫内膜癌的表达情况,分析三者之间的相互联系及临床意义。方法:采用免疫组织化学法及Western blot法检测正常子宫内膜及高中低分化子宫内膜癌组织中PPARγ、ERα和ERβ的表达。结果:PPARγ在子宫内膜癌中表达量明显降低,且随病理分级的进展,呈递减趋势;ERα在正常子宫内膜及高分化子宫内膜癌中表达量无显著性差异(P>0.05),而在中、低分化子宫内膜癌中表达量降低(P<0.05);ERβ表达量仅在低分化子宫内膜癌降低,在正常子宫内膜及高中分化子宫内膜癌中表达量无显著性差异(P>0.05)。Pearson相关分析提示ERα与PPARγ在不同子宫内膜组织中表达量呈正相关(P<0.05),而ERα与ERβ、ERβ与PPARγ间无相关性。结论:PPARγ及ERα表达水平与子宫内膜癌的分化程度、临床分期相关,在子宫内膜癌的发生发展中可能起重要作用。Objective：To investigate the expressions of peroxisome proliferator-activated receptor gamma （PPARγ）, estrogen re-ceptor alpha （ERα）, and estrogen receptor beta （ERβ） in endometrial carcinoma and to analyze their correlations and clinical signifi-cance. Methods：Immunohistochemical assay and Western blot were used to detect the expressions of PPARγ, ERα, and ERβin normal endometrial tissues and well-differentiated, moderately differentiated, and poorly differentiated endometrial carcinomas. Results：PPARγexpression was significantly lower in endometrial carcinoma than in the normal endometrium and was intimately associated with cli-ni-copathologic variables. ERαexpression gradually decreased in moderately and poorly differenti-ated endometrial carcinomas. How-ever, no significant differences were found between the normal endometrium and well-differentiated endometrial carcinoma. ERβex-pression only decreased in the poorly differentiated endometrial carcinoma. No significant association was observed between ERβand clinicopathologic variables. Pearson correlation analysis showed a significant positive cor-relation between the expressions of PPARγand ERα. No correlations were observed between the expressions of ERαand ERβand between that of ERβand PPARγ. Conclusion：The expression lev-els of PPARγand ERαwere significantly associated with the clinicopathologic stage of endometrial carcinoma, and have essential functions in endometrial tumorigenesis and tumor progression.

关 键 词：子宫内膜癌 过氧化物酶体增殖物激活受体Γ 雌激素受体Α 雌激素受体Β 

分 类 号：R737.33[医药卫生—肿瘤]