上皮–间质转化:肿瘤转移的重要调控机制  

Epithelial-mesenchymal Transition: An Important Mechanism for Regulation of Tumor Metastasis

作　　者：陈晓敏[1] 郭俊明[1] 乐东海[2] 夏天[1] 李克强[1,2] 

机构地区：[1]宁波大学医学院,宁波315211 [2]宁波市第二医院,宁波315010

出　　处：《中国细胞生物学学报》2013年第9期1367-1375,共9页Chinese Journal of Cell Biology

基　　金：浙江省自然科学基金(批准号:Y2110961)资助的课题~~

摘　　要：上皮–间质转化(epithelial-mesenchymal transition,EMT)是指上皮细胞在特定生理或病理情况下向间质细胞表型转变的过程。近年来发现,EMT与肿瘤转移密切相关,已成为当前生命科学研究的热点。研究证明,激活TGF-β、Wnt/β-catenin、Notch、Hedgehog、IL-6/STAT3以及NF-κB等信号通路,调控Snail1、Snail2、Twist1、Twist2、ZEB1和ZEB2等转录因子,可诱导EMT进程。此外,许多非编码RNA(如microRNA和lncRNA)也参与肿瘤EMT调控。揭示EMT的分子调控机制以及其与恶性肿瘤的关系,对于预防和治疗癌症具有重要意义。The epithelial-mesenchymal transition （EMT） is a unique process in which cells lose epithelial characteristics and gain mesenchymal properties under special physiological or pathological situations. EMT is proved to be highly relevant to tumor metastasis, and has been a focus of recent biological research. The signaling pathways including TGF-13, Wnt/13-catenin, Notch, Hedgehog, IL-6/STAT3 and NF-nB can trigger EMT in tumor cells by inducing Snaill, Snail2, Twistl, Twist2, ZEB1 and ZEB2 expression. In addition, non-coding RNAs （sueh as microRNAs and lncRNAs） also play critical roles in the regulation of EMT. Thus, the identification of molecular mechanism of EMT in malignant cells might provide a tool to better prevent and treat cancers.

关 键 词：上皮–间质转化 EMT 肿瘤 转移 机制 

分 类 号：R730.2[医药卫生—肿瘤]