双眼竞争范式在双相障碍患者的应用  

Applications of the binocular rivalry paradigm in patients with bipolar disorder

作　　者：朱若霖[1] 叶星[1] 周晓琴[2] 杨静[1] 岳云玲[2] 汪凯[1] 

机构地区：[1]安徽医科大学,合肥230022 [2]合肥市第四人民医院

出　　处：《中国神经精神疾病杂志》2013年第8期449-452,共4页Chinese Journal of Nervous and Mental Diseases

基　　金：重大研究计划培育项目(编号:91232717);国家自然科学基金青年基金项目(编号:31000503);安徽医科大学2012年度校科学研究基金项目(编号:2012xkj049)

摘　　要：目的采用双眼竞争范式,探讨双相障碍患者的意识交替速率。方法纳入30例未服用精神类相关药物的双相障碍患者与30名正常对照,采用双眼竞争范式进行双眼交替速率的检查。结果患者组比对照组双眼竞争意识交替速率减慢([4.59±1.70)s vs(.2.70±0.81)s],差异有统计学意义(P<0.01)。患者组按情绪状态分为2亚组,躁狂组的交替速率比抑郁组快([3.50±0.99)s vs.(5.55±1.63)s,P<0.05],且2组均比对照组慢(均P<0.05)。结论减慢的双眼竞争交替速率有可能作为双相障碍的特征性标志,从而成为双相障碍患者鉴别诊断的手段之一。不同的情绪状态可能会影响竞争的感知交替速率。Objective To investigate perceptual alternating rate in patients with bipolar disorder using binocular ri- valry paradigm. Methods Thirty subjects with bipolar disorder without taking psychotropic medicine and 30 controls were recruited to detect the perceptual alternating rate by using binocular rivalry test. Results The rivalry rate of bipolar group was significantly slower than that of the controls [（4.59±1.70） s vs. （2.70±0.81） s, P〈0.01]. Patients in the bipolar group were then divided into two subgroups according to their emotional state. The rivalry rate of manic subgroup was faster than that of depressive subgroup （P〈0.05）, while the rivalry rate of either subgroups was slower than the control group （P〈0.05）. Conclusion The results provide further evidence to support views of binocular rivalry rates as a trait marker in bipolar disorder, thus as one of the means of the differential diagnosis the of patients with bipolar disorder, and alternation rate may be susceptible to the mood status of participants.

关 键 词：双相障碍 双眼竞争 认知 

分 类 号：R749.4[医药卫生—神经病学与精神病学]