乳腺浸润性导管癌组织FGFR1和Survivin表达临床意义分析  

Expression and significance of FGFR1 and Survivin in invasive ductal carcinoma of breast

作　　者：李庆霞[1] 颜聪亚[1] 闫晓路[1] 邢雅军[1] 隋爱霞[1] 王娟[1] 

机构地区：[1]河北省人民医院肿瘤一科,河北石家庄050051

出　　处：《中华肿瘤防治杂志》2013年第17期1315-1318,1322,共5页Chinese Journal of Cancer Prevention and Treatment

基　　金：河北省科技支撑计划(11276103D-70)

摘　　要：目的:探讨成纤维细胞生长因子受体1(fibroblast growth factor receptor 1,FGFR1)及Survivin蛋白在乳腺浸润性导管癌(invasive ductal carcinoma,IDC)中的表达、意义及两者的相关性。方法:采用免疫组织化学SP法检测81例乳腺IDC组织石蜡标本中FGFR1及Survivin的表达情况。结果:FGFR1及Survivin蛋白阳性表达率分别为29.63%(24/81)和77.78%(63/81)。它们的表达均与患者年龄无关(χ2=0.919,P=0.338;χ2=1.442,P=0.233);但与细胞增殖指数(Ki-67)呈明显正相关(r=0.446,P<0.001;r=0.269,P=0.015);FGFR1的表达与雌激素受体(estrogen receptor,ER)呈正相关性(r=0.285,P=0.010),与孕激素受体(progesterone receptor,PR)、表皮生长因子受体2(human epidermal growth factor receptor 2,HER-2)呈负相关性(r=-0.371,P=0.001;r=-0.372,P=0.001),而与肿瘤大小(χ2=2.222,P=0.329)、腋淋巴结转移(χ2=0.424,P=0.515)、TNM分期(χ2=0.608,P=0.738)和病理组织学分级(χ2=4.514,P=0.105)差异无统计学意义;而Survivin表达与ER的表达(r=-0.145,P=0.195)和PR的表达(r=0.172,P=0.126)无关,与HER-2呈正相关性(r=0.275,P=0.013),并与肿瘤大小(χ2=21.500,P<0.001)、腋淋巴结转移(χ2=4.772,P=0.029)、TNM分期(χ2=10.792,P=0.005)及病理组织学分级(χ2=11.638,P=0.003)密切相关;FGFR1与Survivin表达呈显著正相关,r=0.347,P=0.006。结论:FGFR1和Survivin可能是乳腺IDC患者的不良预后因素;FGFR1及Survivin可能共同促进乳腺癌的细胞增殖、侵袭及转移,联合检测有助于更准确地判断乳腺IDC的预后。OBJECTIVE： To investigate the expressions,significance and correlation between the protein of Survivin and fibroblast growth factor receptor 1 （FGFR1） in invasive ductal carcinoma （IDC） of breast. METHODS： The expressions of Survivin and FGFR1 in 81 cases of IDC were detected with immunohistochemical methods. RESULTS： The percentage of positive expressions of FGFR1 and Survivin in IDC tissues were 29.63 % （24/81） and 77.78 % （63/81） respectively. The expression of FGFR1 and Survivin were no correlation with age（x2 = 0. 919, P= 0. 338; X2 = 1. 442, P= 0. 233 ）, but had significant correlation with the proliferation index/Ki-67 （r= 0. 446, P〈0. 001 ; r= 0.269, P = 0. 015）. The expression of FGFR1 was positively correlated with ER （r= 0. 285, P= 0. 010）, and negatively correlated with PR and HER-2, （r= - 0.371, P = 0. 001, r = - 0.372, P = 0.001 ）. It had no correlation with tumor size, axillary lymph node metastasis, TNM stage and histological grade （X2 = 2.222, P = 0. 329 ; X2 = 0.424, P = 0. 515 ; X2 = 0. 608, P = 0.738 ;X2 = 4.514, P = 0.105）. The expression of Survivin had no correlation with ER, PR （ r = - 0. 145, P = 0. 195 ; r = 0. 172, P = 0. 126）, but had positively relation with HER-2. tumor size, axillary lymph node metastasis, TNM stage and histological grade（r=0. 275,P=0. 013;X2=21.50,P〈0.001;X2=4. 772,P=0.029;;（2=10. 792,P=0.005;X2=11. 638,P= 0. 003）. The expression o{ Survivin had a positive correlation with the expression of FGFR1 （r= 0. 347, P = 0. 006）. CON- CLUSIONS： The expressions of FGFR1 and Survivin may be a poor prognostic factor in patients with IDC;and it may accelerate cell proliferation,invasion and metastasis of the IDC. Combined detection of FGFR1 and Survivin can help to determine the prognosis of IDC more accurately. [

关 键 词：成纤维细胞生长因子受体1 SURVIVIN 乳腺肿瘤 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]