清木丹颗粒治疗湿热瘀毒型乙型肝炎肝硬变30例  

30 Cases of Hepatitis B Cirrhosis of Dampness-heat and Toxic-Stasis Syndrome Treated with Qingmudan Granule

作　　者：宋春荣[1] 席奇[1] 李京涛[1] 刘亚珠[1] 

机构地区：[1]陕西中医学院附属医院,陕西咸阳712000

出　　处：《河南中医》2013年第9期1454-1456,共3页Henan Traditional Chinese Medicine

摘　　要：目的:观察清木丹颗粒治疗湿热瘀毒型乙型肝炎肝硬变的临床疗效。方法:将60例符合湿热瘀毒型乙型肝炎肝硬变患者按随机数字表法分为治疗组和对照组各30例,两组均予常规口服阿德福韦酯抗乙肝病毒治疗,治疗组加用清木丹颗粒,对照组加用水飞蓟宾胶囊,疗程3个月。观察两组治疗前后临床症状、肝功能情况及血清肝纤维化指标的变化情况。结果:治疗后治疗组临床症状及体征均较治疗前明显改善或消失,差异有统计学意义(P<0.05),且与对照组比较差异有统计学意义(P<0.05);两组患者治疗后肝功能比治疗前均明显改善(P<0.01),且治疗组ALT、AST、TBiL、ALB改善优于对照组(P<0.01或P<0.05);治疗后治疗组血清肝纤维化指标均比治疗前改善明显,且优于对照组(P<0.05或P<0.01);治疗组有效率为90.8%,对照组有效率为70.0%,治疗组优于对照组(P<0.05)。结论:清木丹颗粒联合阿德福韦酯能改善湿热瘀毒型乙型肝炎肝硬变患者的临床症状及体征、恢复肝功能、并能有效抗肝纤维化,促进肝组织恢复。Objective： To investigate the clinical therapeutic effect of Qingmudan Granule on Hepatitis B cirrhosis of dampness-heat and toxic-stasis syndrome.Methods： 60 cases were randomly divided into treatment group and control group,with 30 cases in each group.Both groups were given conventional oral adefovir anti-HBV treatment.The treatment group was added with Qingmudan Granule while the control group was added with Silibinin Granule.The course of treatment was three months.The main symptoms and signs,hepatic function and the change of serum index of liver fibrosis before and after treatment were detected.Results： After the treatment,clinical symptoms and signs in treatment group got obviously improved or disappeared compared with those before the treatment,there were significant difference（P0.05）.And there were significant difference compared with control group（P0.05）.The hepatic function of the two groups after the treatment improved evidently compared with that before treatment,and there was significant difference（P0.01）.While the improvement of ALT,AST,TBIL and ALB in treatment group were significantly superior to those in control group（P0.01,P0.05）.The improvement of serum hepatic fibrosis index of treatment group made significant difference compared with that before treatment（P0.05,P0.01）.Total effective rate of treatment group was 90.8%,and control group was 68.3%.The treatment group was better than control group.Conclusion： Qingmudan Granule combined Adefovir has a good effect in improving the clinical symptoms and signs,recovering hepatic function,resisting hepatic fibrosis and enhancing the recovery of patients with hepatitis B cirrhosis of dampness-heat toxic stasis syndrome.

关 键 词：乙型肝炎肝硬变 湿热瘀毒证 清木丹颗粒 水飞蓟宾胶囊 

分 类 号：R575.2[医药卫生—消化系统]