化疗对晚期消化道恶性肿瘤患者血浆D-二聚体的影响  

The Influence of Chemotherapy on D-dimer in Patients with Advanced Digestive Tract Cancer

作　　者：刘莉[1] 丁昌利[1] 张智勇[1] 郑盈[1] 陆震宇[1] 

机构地区：[1]上海市第一人民医院分院肿瘤科,200081

出　　处：《实用癌症杂志》2013年第4期338-340,共3页The Practical Journal of Cancer

摘　　要：目的探讨晚期消化道恶性肿瘤患者化疗前后血浆D-二聚体的变化及临床意义。方法对44例晚期消化道肿瘤恶性癌患者化疗前后血浆D-二聚体水平及20例健康人血浆D-二聚体水平进行检测。结果化疗前晚期消化道恶性肿瘤患者血浆D-二聚体水平与正常对照组比较有显著差异(P<0.01);化疗有效的晚期消化道恶性肿瘤患者化疗后与化疗前血浆D-二聚体水平相比有显著性差异(P<0.05)。结论晚期消化道恶性恶性肿瘤患者普遍存在凝血功能异常,化疗可改善患者的凝血功能,血浆D-二聚体水平可检测化疗疗效。Objective To evaluate the variations of the plasma levels of D-dimer before and after chemotherapy in pa- tients with advanced digestive tract cancer. Methods The plasma levels of D-dimer were detected in 44 patients with advanced digestive tract Caner and 20 normal controls. Results Compared with the control group, the mean values of D-dimer （ D-D ） was significantly higher（ P 〈 0.01 ）in patients with advanced digestive tract cancer. In RR Group, The plasma levels of D-direct was lower in post-chemotherapy patients than in pre-chemotherapy samples （ P 〈 0.05 ）. Conclusion Coagulation disorder is common among advanced digestive tract cancer patients. Chemotherapy may improve the coagulation function of patients with advanced di- gestive tract cancer. D-dimer can detect the efficacy of chemotherapy.

关 键 词：晚期消化道恶性肿瘤 化疗 D-二聚体 

分 类 号：R735[医药卫生—肿瘤]