巨块型子宫颈癌术前^(252)锎腔内后装放疗与术前化疗的对比分析  

Comparative Analysis of Preoperative 252-Californium Brachytherapy and Neoadjuvant Chemotherapy in Bulky Cervical Cancer

作　　者：赖淑贞[1] 廖卫坚[1] 余晓文[1] 胡红波[1] 何剑芬[1] 陈志仁[1] 

机构地区：[1]汕头大学附属粤北人民医院,512026

出　　处：《实用癌症杂志》2013年第4期414-416,共3页The Practical Journal of Cancer

摘　　要：目的探讨术前252锎(252Cf)中子腔内后装放疗和新辅助化疗在巨块型子宫颈癌治疗中的作用。方法 62例行根治性手术治疗的ⅠB～ⅡA期巨块型宫颈癌患者:其中术前放疗组33例,术前接受252Cf腔内后装放疗;术前化疗组29例,术前接受新辅助化疗。结果术前放疗组与术前化疗组有效率分别为90.9%vs.72.4%(P=0.057),组织学完全缓解率分别为24.2%vs.3.4%(P=0.02)。术前放疗组与术前化疗组手术时间分别为(4.3±1.0)h和(4.3±0.8)h,术后尿潴留发生率分别为18.2%和24.1%,差异无统计学意义(P>0.05);术前放疗组术中出血量增多至(784.9±537)ml,术前化疗组为(665.5±342.3)ml,两组比较差异具有统计学意义(P=0.02)。结论巨块型宫颈癌术前252锎中子腔内后装放疗和新辅助化疗均可有效缩小肿块;术前252锎中子腔内后装放疗的疗效是否优于新辅助化疗,还须进一步研究。Objective To investigate the role of preoperative 252-Californium （252 Cf） brachytherapy and neoadjuvant chemotherapy on bulky cervical cancer. Methods 62 patients with stage I B- IIA cervical cancer treated by radical hysterecto- my were examined. 33 cases received preoperative Z52Cf brachytherapy,29 cases received neoadjuvant chemotherapy. Results The response rate of preoperative radiation group and the neoadjuvant chemotherapy group were 90.9% and 72.4% respectively, and there was no significant difference in the efficacy between the two groups （P = 0. 057 ）. There was significant difference in the pathological complete remission rate between the radiation group and the chemotherapy group （ 24.2% vs. 3.4% , P = O. 02 ）. There was no signifieant difference between the radiation group and the chemotherapy group in the duration of operation [ （4.3 ±1. 0） h vs. （4.3 ±0.8） h,P 〉0.05] ,the rate of urinary retention （ 18.2% vs. 24.1% ,P 〉0.05）. The mean blood loss of the radiation group[ （784.9 ± 537 ）ml ]was more than that of the chemotherapy group[ （665.5 ± 342.3 ） ml ], and the difference was significant （ P = 0.02）. Conclusion The preoperative 252Cf braehytherapy and the neoadjuvant chemotherapy can effectively re- duce the tmnor volume of the bulky cervical carcinoma. But whether the preoperative 252 Cf braehytherapy is more effective than the neoadjuvant chemotherapy for bulky cervical cancer need further investigation.

关 键 词：子宫颈癌 252锎 术前辅助放疗 新辅助化疗 

分 类 号：R737.33[医药卫生—肿瘤]