用近红外光拓扑图技术实时跟踪脑血流变化  

NEAR INFRARED SPECTROSCOPY TOPOGRAPHY TRACING THE CEREBRAL HEMODYNAMIC CHANGES IN REAL TIME

作　　者：陈卫国[1] 李鹏程 卢广[2] 胡波[3] 

机构地区：[1]华中理工大学生命科学与技术学院,湖北武汉430074 [2]中国科学院武汉分院磁共振和原子,分子物理国家重点实验室,湖北武汉430074 [3]同济医科大学附属协和医院神经内科,湖北武汉430030

出　　处：《生物物理学报》2000年第3期613-617,共5页Acta Biophysica Sinica

基　　金：国家自然科学基金资助!(批准号 :39770228)

摘　　要：用近红外光大脑拓扑图技术(near-infraredcerebraltopography,NIRStopog raphy) ,对大鼠大脑中动脉线栓梗塞模型的皮层缺血部位进行定位成像。利用氧合血红蛋白和去氧血红蛋白对近红外光的吸收峰值波长分别为850nm和760nm的原理 ,制作了NIRS拓扑仪。分别用NIRS拓扑仪、磁共振成像和解剖样本染色对10只SD雄性大鼠大脑皮层缺血部位进行成像。结果表明 ,NIRS拓扑图所显示的皮层缺血面积与磁共振图象及解剖样本所显示的皮层缺血面积的相关系数分别为0.82(p<0.05)和0.89(p<0.01)。Based on the absorption wavelength of oxyhemoglobin (850nm) and deoxyhemoglobin (760nm) a near infrared spectroscopy (NIRS) and the relative software to measure cerebral hemodynamic changes have been constructed.The cortical ischemia area reflected in the NIRS was compared with that in the magnetic resonance imaging (MRI) and the anatomical sample of the same rat. The results show that there are significant correlations between NIRS topography and MRI (r=0.82,p<0.05) and between NIRS and anatomical sample (r=0.89,p<0.01).

关 键 词：近红外光谱 拓扑图 脑梗塞 预测 实时 

分 类 号：R743.33[医药卫生—神经病学与精神病学]