Genetic variants in telomere-maintenance genes and bladder cancer risk  

端粒维持基因多态性与膀胱癌易感性的关系(英文)

作　　者：Chengyuan Gu Yao Zhu Dingwei Ye 

机构地区：[1]Department of Urology, Fudan University Shanghai Cancer Center [2]Department of Oncology, Shanghai Medical College of Fudan University

出　　处：《The Chinese-German Journal of Clinical Oncology》2013年第9期448-453,共6页中德临床肿瘤学杂志（英文版）

摘　　要：Telomere maintenance genes play an important role in maintaining the integrity of the telomere structure that protects chromosome ends,and telomere dysfunction may lead to tumorigenesis.Genetic variation in telomere maintenance genes has been confirmed.Cumulative evidence shows that the difference of telomere length and stability among the individual depends on the genetic variants of telomere maintenance genes.Genetic variants in telomere maintenance genes may affect telomere length and stability,thus the increased cancer risk.This review intends to summarize the association of genetic variants in telomere maintenance genes with bladder cancer risk.

关 键 词：telomere maintenance genes polymorphism bladder cancer susceptibility 

分 类 号：R737.14[医药卫生—肿瘤]