脂肪酸合成酶和Ki-67在头颈部鳞状细胞癌组织中的表达及其临床意义  

Expression and clinical significance of FAS,Ki-67 in squamous cell carcinoma of the head and neck

作　　者：宋具昆[1] 尹鑫海[1] 黄光磊[1] 赵科[1] 王亚东[1] 

机构地区：[1]贵州省人民医院口腔科,贵州贵阳550002

出　　处：《贵州医药》2013年第4期300-302,共3页Guizhou Medical Journal

摘　　要：目的探讨脂肪酸合成酶和细胞核增殖抗原Ki-67在头颈部鳞状细胞癌组织中的表达情况及其临床意义。方法应用免疫组织化学技术检测60例头颈部鳞状细胞癌标本中癌细胞FAS和Ki-67的表达情况。结果 60例头颈部鳞状细胞癌中FAS阳性率为43.3%(26/60),明显高于癌旁组织(20.0%)和正常组织(10.0%)。头颈部鳞状细胞癌中Ki-67阳性率为46.7%(28/60),明显高于正常组织(10.0%);略低于癌旁组织(30.0%)。Ⅰ、Ⅱ期鳞癌中FAS及Ki-67阳性表达率逐渐升高,但Ⅲ期鳞癌中FAS及Ki-67阳性表达率较Ⅰ、Ⅱ期阳性表达率有所下降。结论 FAS和Ki-67分别是头颈部鳞状细胞癌进展过程的相关指标;两者在头颈部鳞状细胞癌组织中的表达具有一致性。Objective To explore the expression of FAS and Ki-67 in squamous cell carcinoma of the head and neck and their clinical significance. Methods Tissue specimens were collected from 60 patients with SCCHHN, Immunohistochemistry method was used to detect the expression of FAS and Ki-67 in these specimens. The expression levels of FAS and Ki-67 were compared among different tissues. Results The positive expression rate of FAS in SCCHN tissues was 43.3 % which was significantly higher than that in adjacent tissues （20.0 %） and normal tissues （10.0%）. The positive expression rate of FAS in SCCHN tissues of patients with Grade I , II was higher than that of patients with Grade III. The positive expression rate of Ki-67 in SCCHN tissues was 46.7%, which was significantly higher than that in normal tissues （10.0 % ）, and lower than that in adjacent tissues （30.0 % ）. The positive expression rate of Ki-67 in SCCHN tissues of patients with Grade I , II was higher than that of patients with Grade III. Conclusion FAS and Ki-67 were meaningful markers of progression of patients with SCCHN. The FAS and Ki-67 may he more helpful to predict the prognosis of patients with SCCHN. FAS and Ki-67 have a significant positive correlation in SCCHN.

关 键 词：头颈部鳞状细胞癌 脂肪酸合成酶 免疫组织化学 

分 类 号：R73-3[医药卫生—肿瘤] R730.261[医药卫生—临床医学]