血清破骨细胞分化因子和抑制因子检测对肺癌骨转移的诊断价值  

The diagnostic value of serum osteoclast differentiation factor and ihibititory factor in bone metastasis of lung cancer

作　　者：李莉[1] 谭榜云[1] 刘志武[1] 陈明[2] 张艺[3] 

机构地区：[1]兰州大学第一医院检验科,甘肃兰州730000 [2]兰州大学第一医院核医学科,甘肃兰州730000 [3]兰州大学第一医院呼吸科,甘肃兰州730000

出　　处：《国际检验医学杂志》2013年第15期1930-1931,1934,共3页International Journal of Laboratory Medicine

基　　金：甘肃省自然科学研究基金计划项目(1010RJZA120)

摘　　要：目的探讨血清破骨细胞分化因子(ODF)和破骨细胞生成抑制因子(OCIF)水平对肺癌骨转移的诊断价值。方法入选的研究对象为经细胞学和病理学确诊为原发性肺癌的患者(186例):分为骨转移组(104例)和无骨转移组(82例);该院健康体检者(30例)作为对照组;肺部其他疾病组(66例)。采用ELISA测定各组血清ODF和OCIF浓度。结果骨转移组患者血清ODF和OCIF水平分别为(32.22±6.22)ng/L、(41.23±8.13)ng/L明显高于无骨转移组的(8.35±5.42)ng/L、(10.15±4.42)ng/L,差异有统计学意义(P<0.01);骨转移组ODF和OCIF检测的诊断灵敏度为90.38%和86.54%,特异度为86.59%和84.15%;不同肺癌病理类型的骨转移组患者血清ODF和OCIF水平差异无统计学意义(P>0.05)。结论血清ODF和OCIF是诊断肺癌骨转移的重要参考指标,其水平的增高可用于诊断肺癌骨转移的发生。Objective To investigate the diagnostic value of serum osteoclast differentiation factor（ODF） and osteoclastogenesis inhibitory factor（OCIF） levels in bone metastasis of lung cancer. Methods The subiects enrolled were diagnosed with primary lung cancer both in cytology and pathology（186 cases）, which were divided into 2 groups=bone metastasis group（104 cases） and without bone metastasis group（82 cases） ;healthy people who received medical examinations in the hospital（30 cases） were recruited as control group ; patients with other lung disease were also recruited（66 cases）. The serum levels of ODF and OCIF were measured by ELISA. Results The serum levels of ODF and OCIF were （32.22±6.22） ng/L and （41.23±8.13） ng/L respectively in bone me- tastases group, which was significantly higher than those in without bone metastasis group （8.35± 5.42） ng/L, （10.15± 4.42 ） ng/ L, the difference was statistically significant（P〈 0.01）. The diagnostic sensitivities of bone metastasis by the increase of serum ODF and OCIF were 90.38% and 86.54% respectively,the specificities were 86.59% and 84. 15% respectively. Patients＇ serum levels of ODF and OCIF showed no significant difference（P〉0.05） in different pathological types of lung cancer with bone metastases. Conclusion Serum levels of ODF and OCIF are important indicators in bone metastasis,its increase can be used to diagnose lung cancer bone metastasis.

关 键 词：肺肿瘤 骨转移 破骨细胞分化因子 破骨细胞生成抑制因子 

分 类 号：R734.2[医药卫生—肿瘤]