肝硬化患者血清肝纤维化指标联合AFU和AFP检测的临床价值的研究  

Clinical value of combined detection of serum liver fibrosis indicators,AFU and AFP in patients with hepatic cirrhosis

作　　者：顾春瑜[1] 石新慧[1] 王海滨[1] 

机构地区：[1]解放军总医院第一附属医院检验科,北京100048

出　　处：《国际检验医学杂志》2013年第15期1957-1958,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨血清透明质酸(HA)、层黏连蛋白(LN)和Ⅳ型胶原(Ⅳ-C)以及α-L-岩藻糖苷酶(AFU),甲胎蛋白(AFP)水平变化与肝硬化的关系。方法对213例慢性肝病患者和66例健康志愿者的血清HA、LN、Ⅳ-C、AFU和AFP等五项指标进行联合检测分析。结果在慢性迁延性肝炎(CPH)组、慢性活动性肝炎(CAH)组和肝硬化(LC)组,血清HA、LN、和Ⅳ-C的水平呈相似的逐渐升高趋势,与对照组比较明显增高(P<0.01),肝病患者血清AFU和AFP水平均高于健康人。特别是在肝硬化组,两项指标分别是健康人的2.0倍和8.8倍,与健康人的差异有统计学意义(P<0.01)。结论血清HA、LN、Ⅳ-C和AFU、AFP五项指标是慢性肝病向肝硬化转变过程中反映肝纤维化进展的指标,可以为肝硬化的早期诊断和病情监测提供参考。Objeetive To explore the clinical values of serum hyaluronie acid （HC）, laminin （LN）, collagen type iV （IV-C）, AFU and AFC in diagnosis of chronic liver diseases. Methods The levels of serum HA, LN, IV-C, AFU and AFP were detected and analyzed in 213 cases of chronic liver diseases and 66 cases of healthy volunteers. Results The levels of serum HA, LN and IV-C in patients with chronic persisting hepatitis （CPH） ,chronic active hepatitis （CAH） and liver cirrhosis （LC） were all obviously higher than those in healthy volunteers （P〈0.05）. Levels of serum AFU and AFP in LC group are 2.0 and 8.8 times of healthy volun- teers respectively, which significantly increased compared healthy control group. Conclusion Levels of serum H A,LN, IV-C,AFU and AFP can indicate liver fibrosis progression in the transformation from chronic liver disease to hepatic sclerosis. Combined detections of the 5 indicators are helpful in early diagnosis of hepatic cirrhosis.

关 键 词：Α-L-岩藻糖苷酶 甲胎蛋白 肝硬化 

分 类 号：R575.2[医药卫生—消化系统]