3项血清肿瘤标志物检测在结直肠癌诊断中的意义  

The significance of 3 serum tumor markers dection in the diagnosis of colorectal cancer

作　　者：杨雪梅[1] 左向华[1] 孙士欣[1] 张伟[1] 焦汇楠[1] 彭科[1] 虞丹丹[1] 康树伟[1] 陈建魁[1] 

机构地区：[1]中国人民解放军三○七医院检验科,北京100071

出　　处：《国际检验医学杂志》2013年第16期2107-2108,共2页International Journal of Laboratory Medicine

摘　　要：目的评价3项血清肿瘤标志物(CA24-2、CA50和CEA)水平单独及联合检测对结直肠癌的诊断价值。方法采用电化学发光法测定血清CEA水平,ELISA法测定血清CA24-2和CA50水平,选取的病例包括结直肠癌患者72例(结直肠癌组),结直肠良性疾病患者46例(结直肠良性疾病组)和健康体检者48例(健康组)。结果结直肠癌组患者3项肿瘤标志物的水平均明显高于结直肠良性疾病组和健康组(P<0.05)。3项肿瘤标志物联合检测对结直肠癌诊断的特异度高于3项单独检测。结论血清肿瘤标志物CA24-2、CA50和CEA水平单独检测在结直肠癌诊断中有一定的临床意义,联合检测对结直肠癌诊断的特异度比3项单独检测更高。三者联合检测可提高结直肠癌诊断的特异度。Objective To evaluate the diagnostic value of assays for three kinds of serum tumor markers（CA24-2,CA50 and CEA） singly or in combination for colorectal cancer.Methods Electrochemiluminescence was used to measure serum CEA concentrition,ELISA was used to measure serum CA24-2 and CA50 concentritions.The patients enrolled in the study included 72 cases of colorectal cancer（colorectal cancer group）,46 cases of colorectal benign disease（benign colorectal disease group） and 48 healthy people（healthy group）.Results The concentritions of serum tumor markers were significantly higher in patients of colorectal cancer group than those of benign colorectal disease group and healthy group（P＆lt;0.05）.The specificity of the combined assays for 3 tumor markers was higher than single assays.Conclusion Assays for serum CA24-2,CA50 and CEA have clinical value for the diagnosis of colorectal carcinoma,and in combination could enhance the diagnostic specificity.

关 键 词：结直肠肿瘤 肿瘤标记 生物学 CA24-2抗原 CA50抗原 癌胚抗原 

分 类 号：R735.3[医药卫生—肿瘤]