耐热碱性磷酸酯酶(FD-TAP)的三维结构分析  

Analysis of 3D Structrue of the Thermostable Alkaline Phosphatase(FD-TAP)

作　　者：戴林森 王健 高大操 季朝能 盛小禹 毛裕民 

出　　处：《复旦学报（自然科学版）》2000年第4期394-396,共3页Journal of Fudan University：Natural Science

基　　金：国家自然科学基金资助项目!(39870 40 2 )

摘　　要：用计算机图像模拟 ,能量极小化和分子动力学方法 ,以大肠杆菌碱性磷酸酯酶 (BAP)为主要结构模板 ,构建了耐热碱性磷酸酯酶 (FD TAP)的三维结构 ,并分析了它的结构特征 ,从而为酶蛋白的结构。The 3D structure of thermostable alkaline phosphatase(FD TAP) has been modeled, taking Escherichia coli alkaline phosphatase(BAP) as the main structure templet and using computer graphics simulation, energy minimization and molecular dynamics. Its structure character has also been alalysed. These are the good foundation for further study on the relationship among the structure, catalytic reaction activity and thermostability of FD TAP.

关 键 词：磷酸酯酶 同源模建 三维结构分析 工具酶 

分 类 号：Q617[生物学—生物物理学] Q783