血管性轻度认知损害患者血清胱抑素C水平的临床研究  

Changes of serum cystatin C in vascular mild cognitive impairment

作　　者：王为强[1] 张子诚[1] 宇辉[1] 赵宾[1] 

机构地区：[1]安徽医科大学宿州临床学院(安徽省宿州市立医院)神经内科二病区,安徽宿州234000

出　　处：《中国现代医生》2013年第25期26-27,共2页China Modern Doctor

摘　　要：目的探讨血管性轻度认知功能损害(V-MCI)与血清胱抑素C(Cys C)的相关性。方法对70例血管性轻度认知功能损害(V-MCI组)和67例认知功能正常对照组(非V-MCI组)进行详细临床评估和血清Cys C测定。结果 V-MCI组Cys C水平明显高于非V-MCI组(P<0.05),其Cys C水平与MoCA评分中的视空间/执行功能、命名、注意与计算力、语言、延迟回忆各亚项的评分及其总分呈明显负相关(P<0.05)。结论高Cys C可能是V-MCI的独立危险因素,Cys C水平可能与认知功能损害的程度相关。Objective To investigate the relationship between mild vascular cognitive impairment（V-MCI） and serum cystatin C（Cys C）.Methods The levels of Cys C and clinical features were measured in 70 patients with V-MCI and in 67 controls with normal cognition.Results Serum Cys C level of V-MCI group was deepest higher than non-V-MCI group（P 0.05）;serum Cys C level of V-MCI group had negative correlated with total MoCA score（P 0.05） and subitem scores on spatial/executive ability,attention/counting,naming,language,delayed recall（P0.05）.Conclusion The high level of serum cystatin C may be an independent risk factor for V-MCI.The higher level of serum Cystatin C correlated with the degree of cognitive impairment.

关 键 词：胱抑素C 血管性认知损害 血管性痴呆 

分 类 号：R749.13[医药卫生—神经病学与精神病学]