肺癌患者手术前后血清IGF-1水平变化及临床价值  

The preoperative and postoperative changes and clinical value of serum IGF-1 in lung cancer patients

作　　者：华克胜[1] 

机构地区：[1]山东省菏泽市立医院胸外科,山东菏泽274031

出　　处：《中国现代医生》2013年第25期117-118,共2页China Modern Doctor

摘　　要：目的观察肺癌患者手术前后血清IGF-1水平变化,并探讨其对判断手术疗效及临床病理分期的价值。方法应用放射免疫分析法检测38例肺癌患者手术前后的血清IGF-1水平,同时与36例正常人作比较,并分析手术前后血清IGF-1的变化规律及其与病理类型、临床病理分期的关系。结果肺癌患者的血清IGF-1水平明显高于正常对照组(P<0.01),与手术前相比,术后2周时,患者血清IGF-1水平明显降低(P<0.01),不同病理组织学分型的肺癌患者血清IGF-1水平差异不显著(P>0.05),但不同临床病理分期的患者血清IGF-1水平差异明显(P<0.05)。结论肺癌患者血清IGF-1水平变化对判定肺癌的手术疗效及临床分期有一定的临床价值。Objective To observe the changes of serum IGF-1 in lung cancer patients before and after operation, so as to explore the clinical value to operation effect and postoperative surgico-pathologieal stating. Methods The serum IGF-1 in 38 lung cancer patients were detected before and after operation by radioimmunoassay,as well as in 36 nor- mal controls. The variation of serum IGF-1 before and after operation were analyzed,and the relations of IGF-1 and pathological type and postoperative surgico-pathological stating were evaluated. Results The serum IGF-1 in lung cancer patients were significantly higher than normal people（P〈0.01 ）. Compared with those of preoperation,the level of serum IGF-1 decreased dramatically after operation for two weeks（P〈0.01）. There were not obvious differences in the patients with different pathological type （P〉0.05）.But there were significant differences in the patients with different post- operative surgico-pathological stating（P〈0.05）. Conclusion Detection of serum IGF-1 was helpful to judge the oper- ation effect and postoperative surgico-pathological stating of lung cancer.

关 键 词：IGF-1 肺癌 术前 术后 

分 类 号：R734.2[医药卫生—肿瘤]