DcR3和CD105标记的MVD在宫颈癌中的表达及意义  

Expression of DcR3 and micro vessel density marked with CD105 in cervical carcinoma and its significance

作　　者：高四四 

机构地区：[1]上海市松江区泗泾医院妇产科,上海201601

出　　处：《中国现代医生》2013年第26期32-34,F0003,共4页China Modern Doctor

摘　　要：目的观察不同宫颈病变组织中DcR3蛋白和CD105标记的微血管密度(MVD)的表达情况,进而探讨二者间的相互关系。方法采用SP免疫组化法检测42例宫颈癌、24例宫颈上皮内瘤变和18例宫颈正常组织中DcR3蛋白的表达情况,并进行CD105标记的MVD计数。结果宫颈癌组织中DcR3阳性表达率为85.71%,远高于正常宫颈组和CIN组,三组间经Bonferroni法两两比较后差异均有统计学意义(P<0.05)。DcR3表达阳性的宫颈癌组织中MVD亦高于阴性组织(P<0.05),经Spearman秩相关分析发现二者存在线性正相关关系(r=0.42,P<0.05)。结论 DcR3的表达与宫颈癌的发生、发展以及肿瘤血管的生成和转移有关,其可作为临床宫颈癌诊断、治疗及判断预后的新指标。Objective To observe the expression of decoy receptor 3 （DcR3） and micro vessel density（MVD） marked by CDI05 in different cervical lesions,and then to explore the correlation between them. Methods The expression of DcR3 was examined by immunohistochemistry with SP staining method in 42 cases with cervical carcinoma, 24 cases with cervical intra epithelial neoplasia （CIN） and 18 cases with normal cervical. Micro vessel density （MVD） was count ed by endothelial cells immunostained used monoclonal antibody CD105. Results The positive expression rate of DcR3 in cervical cancer was 85.71%, well above the normal cervix and CIN group, the differences were statistically signifi cant （P〈0.05） among the three groups after Bonferroni pairwise comparison. MVD in positive DcR3 expression cervical cancer tissue was also higher than that of negative DcR3 tissue （P 〈 0.05）. At the same time, the Spearman＇s rank cor relation analysis founded that the both exist positive linear correlation （r=0.42, P〈0.05 ）. Conclusion The expression of DcR3 is closely related to cervical carcinoma origination,progression and angiogenesis,metastasis. Which may be used as new indicators of clinical cervical cancer diagnosis, treatment and prognosis.

关 键 词：宫颈癌 诱导受体3 微血管密度 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]