奥拉西坦联合鼠神经生长因子对急性脑梗死脂蛋白磷脂酶A2和S100B蛋白的影响  

The influence of oxiracetam plus mNGF on serum Lp-PLA2 and S100B protein in patients with acute cere-bral infarction

作　　者：段效勇[1] 

机构地区：[1]潍坊市人民医院药剂科,山东省潍坊,261011

出　　处：《中国基层医药》2013年第20期3067-3069,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 探讨奥拉西坦联合鼠神经生长因子对急性脑梗死脂蛋白磷脂酶A2 （Lp-PLA2）和S100B蛋白的影响.方法 124例急性脑梗死患者按照数字表法分为两组,观察组62例,对照组62例,对照组采用常规治疗,观察组在常规治疗的基础上加用奥拉西坦和鼠神经生长因子治疗,共治疗21 d.测定患者血清Lp-PLA2和S100B蛋白.结果 观察组总有效率为98.4％,高于对照组的90.3％（x2=3.96,P＜0.05）.两组治疗后患者血清Lp-PLA2和S100B蛋白均有明显降低,并且与对照组治疗后比较,观察组降低更明显（t=20.9091、3.7273,均P＜0.05）.结论 奥拉西坦联合鼠神经生长因子可以减少急性脑梗死患者血清Lp-PLA2和S100B蛋白的表达.Objective To study the influence of oxiracetam plus mouse nerve growth factor（mNGF） on serum lysophosphatidic acid 2（Lp-PLA2） and S100B protein in patients with acute cerebral infarction. Methods 124 patients with acute cerebral infarction were randomly divided into the observation group（ n = 62 cases） and the control group （ n = 62 cases）. The patients in the control group were treated through the conventional treatment,while the patients in the observation group were treated by oxiracetam plus mNGF on the basis of conventional therapy. They were treated for 21 days. Serum Lp-PLA2 and S100B were detected. Results The total effective rate of the observationgroup was 98.4% ,which was significantly higher than 90.3% of the control group （ X2 = 3.96 ,P 〈 O. 05 ）. Serum LpPLA2 and S100B were decreased in two groups after treatment. Serum Lp-PLA2 and SIOOB in the observation group were lower than those in the control group （ t = 20.9091,3. 7273, all P 〈 0.05 ）. Conclusion Oxiracetam plus mNGF can decrease serum Lp-PLA2 and mNGF in patients with acute cerebral infarction.

关 键 词：脑梗死 奥拉西坦 神经生长因子 磷脂酶A S100蛋白质类 

分 类 号：R743.33[医药卫生—神经病学与精神病学]