On Water： Free Catalysis Approach for the Synthesis of Nitrones from Hydroxamic Acids and Dimethy/ Diethyl Acetylenedicarboxylate  

作　　者：Jian Li Yongqin He Xiaoyu Ren Xiaokang Shi Sizhuo Yang Xiai Gao Guosheng Huang 

机构地区：[1]Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, Gansu 730000, China [2]Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Lanzhou, Gansu 730000, China

出　　处：《Chinese Journal of Chemistry》2013年第8期1003-1006,共4页中国化学（英文版）

摘　　要：Benzohydroxamic acid reacts with dimethyl acetylenedicarboxylate in the presence of 10 mol% NaOAc to gen- erate （E）-N-（1,4-dimethoxy-l,4-dioxobutan-2-ylidene）-l-phenylcarboxamide oxide in good-to-excellent yield in water at room temperature for 2 h, which supplies a simple, efficient and environmentally friendly method to syn- thesize a wide range of nitrones. The benefits of this strategy not only conform to the requirment of green chemisty, but also possess atom economy.Benzohydroxamic acid reacts with dimethyl acetylenedicarboxylate in the presence of 10 mol% NaOAc to gen- erate （E）-N-（1,4-dimethoxy-l,4-dioxobutan-2-ylidene）-l-phenylcarboxamide oxide in good-to-excellent yield in water at room temperature for 2 h, which supplies a simple, efficient and environmentally friendly method to syn- thesize a wide range of nitrones. The benefits of this strategy not only conform to the requirment of green chemisty, but also possess atom economy.

关 键 词：NITRONES benzohydroxamic acid dimethyl acetylenedicarboxylate environmentally friendly greenchemisty 

分 类 号：TQ221.242[化学工程—有机化工] TD954[矿业工程—选矿]