八例虹膜角膜内皮综合征的临床观察与分析  

Clinical observation and analysis 8 cases of iridocorneal endothelial syndrome

作　　者：曹文红 李静贞[1] 洪涛[2] 

机构地区：[1]中国医学科学院北京协和医院眼科 [2]北京市滨河医院眼科

出　　处：《眼科》2000年第5期281-285,共5页Ophthalmology in China

摘　　要：目的 :探讨虹膜角膜内皮 (ICE)综合征的发病机制。方法 :对 8例 ( 1 0只眼 )ICE综合征患者的临床表现、分型及治疗效果进行分析和数据统计。并介绍目前国内外一些新的研究进展。结果 :8例ICE综合征患者临床表现为三型 :原发性进行性虹膜萎缩 7只眼 ,Chandler氏综合征 1只眼 ,Cogan Reese综合征 2只眼。 1 0只眼均继发闭角型青光眼 ,2只眼并发大泡性角膜病变。 9只眼行一次或多次滤过手术 ,1只眼行角膜移植术。结论 :ICE综合征的基本病变是角膜内皮层存在的ICE细胞 ,它们的过度增生导致房角粘连、虹膜萎缩、继发性青光眼和大泡性角膜病变。目前滤过手术及角膜移植术只能在一定程度上缓解眼压及改善角膜质量 ,但不能根本有效地阻止ICE细胞的扩散。Objective:To investigate the etiopathogenesis of iridocorneal endothelial(ICE)syndrome.Method:Clinical features,types and therapeutic results of 8 patients(10 eyes)with ICE syndrome were analysed.Results:8 patients(10 eyes) with ICE syndrome were 3 types:progressive iris atrophy in 7 eyes,Chandler′s syndrome in 1 eye and Cogan-Reese syndrome in 2 eyes.They were all complicated with glaucoma,and 2 eyes had decompensation of corneal endothelium.Trabeculectomy was performed in 9 eyes,and cornea transplantation in 1 eye.Conclusion:Literatures show that the basic lesion of ICE syndrome is ICE cell in the corneal endothelium,which can proliferate excessively,result to adhesion of,iridocorneal angle,atrophy of iris,glaucoma and decompensation of corneal endothelium.Trabeculectomy and transplantation can only control intraocular pressure and improve transparency of cornea partyly,but can′t prevent a proliferation of ICE cell and extending to the chamber angle.

关 键 词：虹膜角膜内皮综合征 继发性青光眼 临床分析 

分 类 号：R772.2[医药卫生—眼科]