吸烟对长期服用抗精神病药物所致锥体外系副作用的影响  

The affect of smoking on EPS in patients who chronically use antipsychotic medication

作　　者：何怡发[1] 王定省[1] 宋立升[1] 

机构地区：[1]上海市精神卫生中心,201108

出　　处：《上海精神医学》2000年第3期141-142,共2页Shanghai Archives of Psychiatry

摘　　要：目的 了解吸烟对住院长期服用抗精神病药物的精神分裂症病人出现锥外系副作用的影响。方法 样本共288例,分为吸烟与非吸烟两组。结果 两组间AIMS总分和Sampson量表及量表主要单项分均无显著差异(P>0.05)。相关分析结果显示,每日吸烟量与AIMS总分和Sampson量表总分及主要单项分无显著相关(P>0.05),而吸烟时间与AIMS总分和Sampson量表总分及主要单项分呈显著相关(P<0.05)。结论 锥外系副作用的严重程度与烟龄有一定关系,烟龄短的病人,吸烟后锥外系反应的减轻较明显,烟量与锥外系反应无显著相关。Objectives: To investigate the influence of smoking on EPS among schizophrenic inpa-tients who chronically use antipsychotic medication. Method: 288 cases were divided into two groups, smoker and nonsmoker. Results: There are no significant differences on AIMS total score, Sampson main item score and total score between two groups (P>0. 05), There are no significant relations between the dose of smoke and the scores of AIMS and Sampson (P>0. 05), but the time of smoke is significantly related to the scores of AIMS and Sampson (P<0. 05). Conclusion; The severity of EPS is related to term of smoke. There is no significant relation between dose of smoking and EPS.

关 键 词：吸烟 锥外系反应 精神分裂症 精神病药物 

分 类 号：R749[医药卫生—神经病学与精神病学]